Anti-DYRK3 antibody (ab236602)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-DYRK3 antibody
See all DYRK3 primary antibodies -
Description
Rabbit polyclonal to DYRK3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human DYRK3 aa 1-300.
Database link: O43781 -
Positive control
- IHC-P: Human pancreatic tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.03% Proclin
Constituents: PBS, 50% Glycerol -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
Purity >95%. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab236602 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/50 - 1/200. |
Target
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Function
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. -
Tissue specificity
Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. -
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Contains 1 protein kinase domain. -
Post-translational
modificationsAutophosphorylated on tyrosine residues. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 8444 Human
- Omim: 603497 Human
- SwissProt: O43781 Human
- Unigene: 164267 Human
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Alternative names
- Dual specificity tyrosine (Y) phosphorylation regulated kinase 3 antibody
- Dual specificity tyrosine phosphorylation-regulated kinase 3 antibody
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DYRK3 antibody (ab236602)Paraffin-embedded human pancreatic tissue stained for DYRK3 using ab236602 at 1/100 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.
References
ab236602 has not yet been referenced specifically in any publications.
