Key features and details
- Rabbit polyclonal to Dystrophia myotonica protein kinase / DMPK
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Dystrophia myotonica protein kinase / DMPK antibody
See all Dystrophia myotonica protein kinase / DMPK primary antibodies
DescriptionRabbit polyclonal to Dystrophia myotonica protein kinase / DMPK
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Recombinant full length protein corresponding to Human Dystrophia myotonica protein kinase/ DMPK aa 1-629.
Database link: NP_004400.4
- WB: HeLa and Dystrophia myotonica protein kinase / DMPK transfected 293T cell lysates.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab102804 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 70 kDa.|
FunctionCritical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
Tissue specificityMost isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
Involvement in diseaseDefects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
- Information by UniProt
- DM 1 antibody
- DM antibody
- DM kinase antibody
Anti-Dystrophia myotonica protein kinase / DMPK antibody (ab102804) at 1/500 dilution + HeLa cell lysate at 50 µg
Predicted band size: 70 kDa
All lanes : Anti-Dystrophia myotonica protein kinase / DMPK antibody (ab102804) at 1/500 dilution
Lane 1 : Dystrophia myotonica protein kinase / DMPK transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell line
Lysates/proteins at 25 µg per lane.
Predicted band size: 70 kDa
ab102804 has not yet been referenced specifically in any publications.