• Product name
  • Description
    Goat polyclonal to DYX1C1
  • Host species
  • Specificity
    This antibody is expected to recognise only one of the three reported isoforms of DYX1C1, isoform a.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Predicted to work with: Mouse, Rat, Human, Chimpanzee
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 408-420 of DYX1C1

  • Positive control
    • Human brain lysate. Lysates of COS1 cells transfected with full length recombinant Human DYX1C1.



Our Abpromise guarantee covers the use of ab31287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 µg/ml. Detects a band of approximately 48, 75 kDa.

In addition, a minor band of 24kDa is detected consistent with observations with N-terminal specific antibodies. The 75kDa band is visible in the non-transfected COS1 also (first lane) and is therefore non-specific.We call for caution when this product is used in other assays than Western blot.

IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function
    Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
  • Tissue specificity
    Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
  • Involvement in disease
    Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
  • Sequence similarities
    Contains 1 CS domain.
    Contains 3 TPR repeats.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dyslexia susceptibility 1 candidate 1 antibody
    • Dyslexia susceptibility 1 candidate gene 1 protein antibody
    • DYX1 antibody
    • DYX1C1 antibody
    • DYXC1 antibody
    • DYXC1_HUMAN antibody
    • EKN1 antibody
    • FLJ37882 antibody
    • MGC70618 antibody
    • RD antibody
    see all


  • ab31287 (5μg/ml) staining DYX1C1 in paraffin embedded Human Cerebral Cortex following steamed antigen retrieval with citrate

    buffer pH 6 and AP-staining shows cytoplasmic staining in some neuronal cells.

  • All lanes : Anti-DYX1C1 antibody (ab31287) at 0.1 µg/ml

    Lane 1 : COS1 cell lysates untransfected
    Lane 2 : COS1 cell lysates transfected with full length recombinant Human DYX1C1

    Observed band size: 48,75 kDa
    why is the actual band size different from the predicted?
    Additional bands at: 24 kDa (possible non-specific binding)


This product has been referenced in:
See 1 Publication for this product

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