Key features and details
- Irreversible, selective, potent cysteine protease inhibitor
- CAS Number: 66701-25-5
- Purity: > 99%
- Soluble in water to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameE-64, cysteine protease inhibitor
DescriptionIrreversible, selective, potent cysteine protease inhibitor
- N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide
Irreversible, potent, and selective cysteine protease inhibitor (IC50 values for cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively). Does not inhibit serine proteases (except trypsin).
Chemical name(2R,3R)-3-[[(2S)-1-[4-(Diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141418 has not yet been referenced specifically in any publications.