Key features and details
- Vanilloid receptor (VR1) agonist
- CAS Number: 404-86-4
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Capsicum sp.
Product name(E)-Capsaicin, Vanilloid receptor agonist
DescriptionVanilloid receptor (VR1) agonist
This product is manufactured by BioVision, an Abcam company and was previously called 2521 Capsaicin. 2521-250 is the same size as the 250 mg size of ab141000.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab141000, (E)-Capsaicin, Vanilloid receptor agonist
Capsaicin induces Ca2+ influx via activation of TRPV1 channels expressed in C6 cells. Cells were loaded with Fluo-3 AM (ab145254) and stimulated with Capsaicin (ab141000). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application (at 20 seconds) of 0-10 µM Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141000 has been referenced in 4 publications.
- Zhang S et al. Dramatic Effect of Botulinum Toxin Type A on Hypertrophic Scar: A Promising Therapeutic Drug and Its Mechanism Through the SP-NK1R Pathway in Cutaneous Neurogenic Inflammation. Front Med (Lausanne) 9:820817 (2022). PubMed: 35308522
- Lv Z et al. TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway. Cell Death Dis 12:504 (2021). PubMed: 34006826
- Testa G et al. The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V. J Neurosci 39:9702-9715 (2019). PubMed: 31685654
- Qian K et al. Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways. Molecules 21:N/A (2016). PubMed: 27775662