(E)-Capsaicin, Vanilloid receptor agonist (ab141000)

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Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
  • Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)

Key features and details

  • Vanilloid receptor (VR1) agonist
  • CAS Number: 404-86-4
  • Purity: > 98%
  • Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Form / State: Solid
  • Source: Capsicum sp.

Overview

  • Product name

    (E)-Capsaicin, Vanilloid receptor agonist

  • Description

    Vanilloid receptor (VR1) agonist

  • Purity

    > 98%

  • CAS Number

    404-86-4

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

  • Molecular weight

    305.42

  • Molecular formula

    C18H27NO3

  • PubChem identifier

    2548

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1ccc(cc1OC)CNC(=O)CCCC/C=C/C(C)C

  • Source

    Capsicum sp.

  • Research areas

Associated products

    Images

    • Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
      Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
      2D chemical structure image of ab141000, (E)-Capsaicin, Vanilloid receptor agonist
    • Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
      Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
      Capsaicin induces Ca2+ influx via activation of TRPV1 channels expressed in C6 cells. Cells were loaded with Fluo-3 AM (ab145254) and stimulated with Capsaicin (ab141000). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application (at 20 seconds) of 0-10 µM Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (2)

    Publishing research using ab141000? Please let us know so that we can cite the reference in this datasheet.

    ab141000 has been referenced in 2 publications.

    • Testa G  et al. The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V. J Neurosci 39:9702-9715 (2019). PubMed: 31685654
    • Qian K  et al. Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways. Molecules 21:N/A (2016). PubMed: 27775662

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