(E)-Capsaicin, Vanilloid receptor agonist (ab141000)

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Overview

  • Product name

    (E)-Capsaicin, Vanilloid receptor agonist

  • Description

    Vanilloid receptor (VR1) agonist

  • Biological description

    Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.

  • Purity

    > 98%

  • CAS Number

    404-86-4

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

  • Molecular weight

    305.42

  • Molecular formula

    C18H27NO3

  • PubChem identifier

    2548

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1ccc(cc1OC)CNC(=O)CCCC/C=C/C(C)C

  • Source

    Capsicum sp.

  • Research areas

Images

  • Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
    Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
    Capsaicin induces Ca2+ influx via activation of TRPV1 channels expressed in C6 cells. Cells were loaded with Fluo-3 AM (ab145254) and stimulated with Capsaicin (ab141000). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application (at 20 seconds) of 0-10 µM Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab141000? Please let us know so that we can cite the reference in this datasheet.

ab141000 has not yet been referenced specifically in any publications.

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