Key features and details
- Rabbit polyclonal to e-LOX-3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-e-LOX-3 antibody
DescriptionRabbit polyclonal to e-LOX-3
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment corresponding to Human e-LOX-3.
- Human fetal lung lysate, Human fetal skin tissue
Previously labelled as ALOXE3.
FormLyophilized:Reconstitute in 200µl Steriled Distilled Water
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab118470 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 81 kDa.|
|IHC-P||1/100 - 1/500.|
FunctionIntroduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
Tissue specificityPredominantly expressed in skin.
PathwayLipid metabolism; leukotriene D4 biosynthesis.
Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
Sequence similaritiesBelongs to the lipoxygenase family.
Contains 1 lipoxygenase domain.
Contains 1 PLAT domain.
- Information by UniProt
- ALOXE3 antibody
- Arachidonate lipoxygenase 3 antibody
- e LOX 3 antibody
ab118470 has not yet been referenced specifically in any publications.