Overview

  • Product name

    Anti-E1 Ubiquitin Activating Enzyme 1/UBA1 antibody - C-terminal
    See all E1 Ubiquitin Activating Enzyme 1/UBA1 primary antibodies
  • Description

    Rabbit polyclonal to E1 Ubiquitin Activating Enzyme 1/UBA1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human, a wide range of other species
  • Immunogen

    Synthetic peptide corresponding to Human E1 Ubiquitin Activating Enzyme 1/UBA1 aa 1040-1058 (C terminal).
    Sequence:

    CNDESGEDVEVPYVRYTIR


    Database link: P22314

  • General notes

     This product was previously labelled as E1 Ubiquitin Activating Enzyme

     

Properties

Applications

Our Abpromise guarantee covers the use of ab195425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 118 kDa.

Target

  • Function

    Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
  • Pathway

    Protein modification; protein ubiquitination.
  • Involvement in disease

    Defects in UBA1 are the cause of spinal muscular atrophy X-linked type 2 (SMAX2) [MIM:301830]; also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.
  • Sequence similarities

    Belongs to the ubiquitin-activating E1 family.
  • Post-translational
    modifications

    ISGylated.
  • Information by UniProt
  • Database links

  • Alternative names

    • A1S9 antibody
    • A1S9 protein antibody
    • A1S9T and BN75 temperature sensitivity complementing antibody
    • A1S9T antibody
    • A1ST antibody
    • AMCX1 antibody
    • CFAP124 antibody
    • CTD-2522E6.1 antibody
    • GXP 1 antibody
    • GXP1 antibody
    • MGC4781 antibody
    • POC20 antibody
    • POC20 centriolar protein homolog antibody
    • Protein A1S9 antibody
    • SMAX2 antibody
    • Uba1 antibody
    • UBA1, ubiquitin-activating enzyme E1 homolog A antibody
    • UBA1_HUMAN antibody
    • UBA1A antibody
    • UBE 1 antibody
    • UBE 1X antibody
    • UBE1 antibody
    • UBE1X antibody
    • Ubiquitin activating enzyme E1 antibody
    • Ubiquitin-activating enzyme E1 antibody
    • Ubiquitin-like modifier-activating enzyme 1 antibody
    see all

References

ab195425 has not yet been referenced specifically in any publications.

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