Overview

  • Product name

    E6 Berbamine, calmodulin (CaM) antagonist
  • Description

    Selective, cell-permeable calmodulin (CaM) antagonist
  • Biological description

    Selective, cell-permeable CaM antagonist. Berbamine derivative. Inhibits calmodulin-dependent MYLK and PDE I (IC50 values are 8 and 0.53 μM for MYLK and PDE1 respectively).
  • Purity

    > 98%
  • CAS Number

    73885-53-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate
  • Molecular weight

    757.80
  • Molecular formula

    C44H43N3O9
  • PubChem identifier

    6610268
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC(=O)C8=CC=C(C=C8)[N+](=O)[O-])OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Virginio C  et al. Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives. Neurosci Lett 381:299-304 (2005). Read more (PubMed: 15896488) »
  • Zhu HJ & Liu GQ Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. Acta Pharmacol Sin 24:1143-9 (2003). Read more (PubMed: 14627500) »
  • Hu ZY  et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol 44:1543-7 (1992). Read more (PubMed: 1417979) »

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