May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.
Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.
During the cell cycle, expression disappears during mitosis.
Immunohistochemical analysis of formalin fixed and paraffin embedded Human cerebellum tissue labeling EAPP with ab171610 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot - Anti-EAPP antibody - C-terminal (ab171610)
Anti-EAPP antibody - C-terminal (ab171610) at 1/100 dilution + WiDr cell line lysate at 35 µg