Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab37649 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionMay play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).
Tissue specificityExpressed in several cell lines tested, including primary and transformed cell lines.
Sequence similaritiesBelongs to the peptidase M24 family.
modificationsPhosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent.
Cellular localizationCytoplasm. Nucleus > nucleolus. Tranlocates to the nucleus upon treatment with HRG.
- Information by UniProt
- 38kDa antibody
- AA672939 antibody
- Cell cycle protein p38 2G4 homolog antibody
Anti-EBP1 antibody (ab37649) at 1/2000 dilution + E coli derived fusion protein
Goat anti IgY HRP at 1/1000 dilution
Developed using the ECL technique.
Predicted band size: 44 kDa
Observed band size: 41 kDa why is the actual band size different from the predicted?
The arrow next to the image points to the EBP1 recombinant protein.
ab37649 has not yet been referenced specifically in any publications.