Overview

  • Product name

    EBPC, Aldose reductase inhibitor
  • Description

    Potent aldose reductase inhibitor
  • Biological description

    Potent aldose reductase inhibitor. Inhibits PGF2α production. Enhances ERK activity. Potentiates anticancer effects of cisplatin (ab141398) and doxorubicin (ab120629).
  • Purity

    > 99%
  • CAS Number

    4450-98-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Ethyl 1-benzyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxylate
  • Molecular weight

    261.28
  • Molecular formula

    C14H15NO4
  • PubChem identifier

    54677973
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)C1=C(C(=O)N(C1)CC2=CC=CC=C2)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bresson E  et al. The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3:98 (2012). Read more (PubMed: 22654757) »
  • Shen Y  et al. Thiol-disulfide exchanges modulate aldo-keto reductase family 1 member B10 activity and sensitivity to inhibitors. Biochimie 92:530-7 (2010). Read more (PubMed: 20144905) »
  • Lee EK  et al. Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anticancer Drugs 13:859-68 (2002). Read more (PubMed: 12394272) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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