Ebselen, mimic of glutathione peroxidase (ab142424)
Key features and details
- Seleno-organic compound, antioxidant, mimic of glutathione peroxidase
- CAS Number: 60940-34-3
- Purity: > 98%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ebselen, mimic of glutathione peroxidase -
Description
Seleno-organic compound, antioxidant, mimic of glutathione peroxidase -
Biological description
Seleno-organic compound, antioxidant, mimic of glutathione peroxidase. Inhibitor of lipoxygenases, NO synthases, NADPH oxidase, protein kinase C and H+/K(+)-ATPase producing anti-inflammatory effects. -
Purity
> 98% -
CAS Number
60940-34-3 -
Chemical structure
Properties
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Chemical name
2-Phenyl-1,2-benzoselenazol-3-one -
Molecular weight
274.18 -
Molecular formula
C13H9NOSe -
PubChem identifier
3194 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab142424 has been referenced in 2 publications.
- Poser SW et al. Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery. FASEB J 33:9235-9249 (2019). PubMed: 31145643
- Adeosun SO et al. A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity. React Oxyg Species (Apex) 5:35-45 (2018). PubMed: 29379885