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    ebv-latent-membrane-protein-1-antibody-cs-1-4-ab78113.pdf

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Microbiology Organism Virus DNA Virus double stranded DNA Virus Epstein Barr
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Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4] (ab78113)

  • Datasheet
  • SDS
Reviews (4)Q&A (3)References (24)

Product price, shipping and contact information

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Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Key features and details

  • Mouse monoclonal [CS 1-4] to EBV Latent Membrane Protein 1
  • Suitable for: WB, IP, IHC-P, IHC-Fr
  • Isotype: IgG1

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Overview

  • Product name

    Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]
    See all EBV Latent Membrane Protein 1 primary antibodies
  • Description

    Mouse monoclonal [CS 1-4] to EBV Latent Membrane Protein 1
  • Host species

    Mouse
  • Specificity

    This antibody is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This is in fact four pooled antibodies which collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates.
  • Tested applications

    Suitable for: WB, IP, IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Epstein-Barr virus
  • Immunogen

    Fusion protein corresponding to EBV Latent Membrane Protein 1.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Clonality

    Monoclonal
  • Clone number

    CS 1-4
  • Myeloma

    x63-Ag8.653
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

    • Microbiology
    • Organism
    • Virus
    • DNA Virus
    • double stranded DNA Virus
    • Epstein Barr

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant EBV Latent Membrane Protein 1 (His tag) (ab240835)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab78113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB (2)
Use at an assay dependent concentration. Predicted molecular weight: 57-66 kDa.
IP
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
IHC-Fr
Use at an assay dependent concentration.
Notes
WB
Use at an assay dependent concentration. Predicted molecular weight: 57-66 kDa.
IP
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
IHC-Fr
Use at an assay dependent concentration.

Target

  • Relevance

    EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
  • Database links

    • Entrez Gene: 3783750 Epstein-Barr virus
    • SwissProt: P0C741 Epstein-Barr virus
    • Alternative names

      • BNLF1 antibody
      • EBV antibody
      • Epstein Barr virus antibody
      • HHV4 antibody
      • Human Herpesvirus 4 antibody
      • Latent membrane protein 1 antibody
      • LMP1 antibody
      see all

    Protocols

    • Immunoprecipitation protocols
    • Immunohistochemistry protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (24)

    Publishing research using ab78113? Please let us know so that we can cite the reference in this datasheet.

    ab78113 has been referenced in 24 publications.

    • Ye D  et al. LMP1 Up-regulates Calreticulin to Induce Epithelial-mesenchymal Transition via TGF-ß/Smad3/NRP1 Pathway in Nasopharyngeal Carcinoma Cells. J Cancer 11:1257-1269 (2020). PubMed: 31956372
    • Shi F  et al. Wild-type IDH2 contributes to Epstein-Barr virus-dependent metabolic alterations and tumorigenesis. Mol Metab 36:100966 (2020). PubMed: 32224436
    • Wang ZH  et al. CD47 Overexpression Is Associated with Epstein-Barr Virus Infection and Poor Prognosis in Patients with Nasopharyngeal Carcinoma. Onco Targets Ther 13:3325-3334 (2020). PubMed: 32368091
    • Gu J  et al. Matrine inhibits the growth of natural killer/T-cell lymphoma cells by modulating CaMKII?-c-Myc signaling pathway. BMC Complement Med Ther 20:214 (2020). PubMed: 32641029
    • Shi F  et al. EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter. Theranostics 9:2424-2438 (2019). PubMed: 31131045
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-7 of 7 Abreviews or Q&A

    Western blot abreview for Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]

    Average
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (EBV transformed B cells)
    Gel Running Conditions
    Reduced Denaturing (10%)
    Loading amount
    10 µg
    Specification
    EBV transformed B cells
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 21°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jul 08 2015

    Immunocytochemistry abreview for Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2.5% · Temperature: 20°C
    Sample
    Mouse Cultured Cells (lymphocyte)
    Specification
    lymphocyte
    Permeabilization
    Yes - acetone
    Fixative
    Methanol
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 23 2015

    Western blot abreview for Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Loading amount
    100 µg
    Gel Running Conditions
    Non-reduced Non-Denaturing (Native) (4-12% gel)
    Sample
    Human Cell lysate - whole cell (PBMC)
    Specification
    PBMC
    Treatment
    EBV for 14days
    Blocking step
    BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 23 2015

    Immunocytochemistry abreview for Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2.5% · Temperature: 25°C
    Sample
    Mouse Cultured Cells (lymphoma)
    Specification
    lymphoma
    Permeabilization
    Yes - Acetone
    Fixative
    Methanol
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 23 2015

    Question

    Vielen, lieben Dank für Ihre detaillierte Antwort!

    Ich bräuchte allerdings leider wirklich einen Antikörper, der extracellulär bindet.

    Plant abcam zufällig, so einen herzustellen, oder hat vielleicht schon einen, der nur noch nicht auf dem Markt ist?

    Vielen, herzlichen DAnk!
    Frohe Weihnachten!

    Read More

    Abcam community

    Verified customer

    Asked on Jan 02 2013

    Answer

    Vielen Dank für Ihre Antwort.

    Leider muss ich Ihnen bestätigen, dass wir keinen Antikörper gegen die extrazelluläre Domäne in Produktion haben.

    Ich werde diesen Vorschlag allerdings gerne weitergeben. Leider kann ich damit aber nicht garantieren, dass dieser Antikörper tatsächlich ins Programm aufgenommen wird.

    Ich möchte Sie deshalb gerne darauf hinweisen, dass wir einen Service für Spezialanfertigungen von Antikörpern haben.

    http://www.epitomics.com/services/

    Bitte lassen Sie mich wissen, ob Sie interessiert sind. Ich werde Sie dann gerne an die zuständige Person weiterleiten.

    Ich wünsche Ihnen ein Frohes Neues Jahr 2013 und verbleibe

    Read More

    Abcam Scientific Support

    Answered on Jan 02 2013

    Question

    Would ab78113 recognise Rhesus monkey tissue?

    Read More

    Abcam community

    Verified customer

    Asked on Oct 20 2011

    Answer

    Thank you for contacting Abcam. I have tried blasting the human EBV-LMP1 sequences against the rhesus monkey database and I cannot seem to get a hit for the rhesus EBV sequence (the only hit is for unnamed protein product, #21103, which has a 70% homolgy for huEBV). I have also tried to find the EBV rhesus sequence in swiss prot, but I cannot find it there either. Therefore I cannot confirm if ab78113 would react with the rhesus monkey tissue. I was wondering if you knew of the accession number for the sequence (rhesus)? If so, I could do the alignment for see if the antibody would work for you. I look forward to your reply.

    Read More

    Abcam Scientific Support

    Answered on Oct 20 2011

    Question

    Dear sir\madam, thanks for your cooperation and response. please we also looking for a secondary antibody: Goat polyclonal Secondary Antibody to Mouse IgG - H&L (FITC) (ab6785) and Anti-beta Actin antibody [AC-15] (ab6276). also please let me know if it is compatible with the three previous primary antibodies.

    Read More

    Abcam community

    Verified customer

    Asked on Sep 19 2011

    Answer

    Thank you for contacting us. The secondary antibody ab6785 (goat anti-mouse IgG, FITC-conjugated) is a suitable secondary for the three primary antibodies you asked about (ab78113, ab90543, and ab3280), as well as ab6276. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Sep 19 2011

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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