Overview

  • Product name

  • Description

    Rabbit polyclonal to ECE2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human ECE2 (internal sequence).
    Database link: O60344

  • Positive control

    • Human colon and gastric cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40 - 1/200.

Target

  • Relevance

    Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity. Tissue specificity: Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). Similarity: In the N-terminal section; belongs to the methyltransferase superfamily. In the C-terminal section; belongs to the peptidase M13 family.
  • Cellular localization

    Golgi apparatus membrane. Cytoplasmic granule membrane.
  • Database links

Images

  • Immunohistochemical analysis of paraffin-embedded human gastric cancer tissue, labeling ECE2 with ab197378 at a 1/40 dilution. 

  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue, labeling ECE2 with ab197378 at a 1/40 dilution. 

References

ab197378 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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