Overview

  • Product name

  • Description

    Rabbit polyclonal to Eco1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Eco1 aa 29-74.
    Sequence:

    QDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAA


    Database link: Q5FWF5

  • Positive control

    • MCF7, Raw264.7 and H9C2 whole cell lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab192503 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab192503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 95 kDa.

Target

  • Function

    Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
  • Tissue specificity

    Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
  • Sequence similarities

    Belongs to the acetyltransferase family. GCN5 subfamily.
  • Domain

    The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process.
  • Post-translational
    modifications

    Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Nucleus. Chromosome. Nuclear at interphase, associated with chromosomes during mitosis.
  • Information by UniProt
  • Database links

  • Alternative names

    • A930014I12Rik antibody
    • CTF antibody
    • CTF7 homolog 1 antibody
    • CTF7, S. cerevisiae, homolog of, 1 antibody
    • ECO1 antibody
    • ECO1 homolog 1 antibody
    • ECO1, S. cerevisiae, homolog of, 1 antibody
    • EFO1 antibody
    • EFO1p antibody
    • ESCO1 antibody
    • ESCO1_HUMAN antibody
    • ESO1 antibody
    • ESO1 homolog 1 antibody
    • ESO1, S. pombe, homolog of, 1 antibody
    • Establishment factor like protein 1 antibody
    • Establishment factor ortholog 1 antibody
    • Establishment factor-like protein 1 antibody
    • Establishment of cohesion 1 homolog 1 antibody
    • Establishment of cohesion 1, S. cerevisiae, homolog of antibody
    • establishment of sister chromatid cohesion N-acetyltransferase 1 antibody
    • hEFO1 antibody
    • HGNC:24645 antibody
    • KIAA1911 antibody
    • N acetyltransferase ESCO1 antibody
    • N-acetyltransferase ESCO1 antibody
    see all

Images

  • All lanes : Anti-Eco1 antibody (ab192503)

    Lane 1 : MCF7 whole cell lysate
    Lane 2 : Raw264.7 whole cell lysate
    Lane 3 : H9C2 whole cell lysate

    Predicted band size: 95 kDa

References

ab192503 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab192503.
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