Overview

  • Product name

    Econazole nitrate, Imidazole antifungal agent
  • Description

    Imidazole antifungal agent
  • Biological description

    Imidazole antifungal agent. Inhibits Ca2+ inward current. Increases parasitic ROS content. Shows antifungal and antiparasitic effects (IC50 = 11 μM, Leishmania intracellular amastigotes) in vivo.
  • Purity

    > 99%
  • CAS Number

    24169-02-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
  • Molecular weight

    444.70
  • Molecular formula

    C18H15Cl3N2O.HNO3
  • PubChem identifier

    68589
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=C(C(=C1)C(CN2C=CN=C2)OCC3=CC=C(C=C3)Cl)Cl)Cl).[N+]([O-])(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mesquita JT  et al. Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole. Mol Cell Biochem 389:293-300 (2014). Read more (PubMed: 24374794) »
  • Lai ZR  et al. Effect of BayK 8644 on [Ca²?]i and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol 56:318-25 (2013). Read more (PubMed: 24495178) »
  • El Hammi E  et al. Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole. FEBS J 279:4565-75 (2012). Read more (PubMed: 23095020) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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