Key features and details
- Rabbit polyclonal to EDA
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-EDA antibody
See all EDA primary antibodies
DescriptionRabbit polyclonal to EDA
Specificityab198022 detects endogenous levels of total EDA protein.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Fusion protein corresponding to Human EDA (C terminal). BC126143. The identity of the protein fusion partner is GST.
Database link: Q92838
- Human liver cancer tissue and human breast cancer tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198022 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200.|
FunctionSeems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
Tissue specificityNot abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
Involvement in diseaseDefects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
Sequence similaritiesBelongs to the tumor necrosis factor family.
Contains 1 collagen-like domain.
Processing by furin produces a secreted form.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- ECTD1 antibody
- Ectodermal dysplasia 1, anhidrotic antibody
- Ectodermal dysplasia protein antibody
ab198022 has been referenced in 2 publications.
- Escouflaire C et al. ? de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia. BMC Genomics 20:715 (2019). PubMed: 31533624
- Liu N et al. Let-7b regulates alpaca hair growth by downregulating ectodysplasin A. Mol Med Rep 17:4688-4694 (2018). PubMed: 29344666