Overview

  • Product name

  • Description

    Rabbit polyclonal to EDA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human EDA aa 160-210 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    SKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIP G


    Database link: Q92838

  • Positive control

    • Mouse embryo and rat placenta tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab203075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

(or 1/50 - 1/200 using a fluorescent secondary antibody).

Target

  • Function

    Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
  • Tissue specificity

    Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
  • Involvement in disease

    Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
    Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
  • Sequence similarities

    Belongs to the tumor necrosis factor family.
    Contains 1 collagen-like domain.
  • Post-translational
    modifications

    N-glycosylated.
    Processing by furin produces a secreted form.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ECTD1 antibody
    • Ectodermal dysplasia 1, anhidrotic antibody
    • Ectodermal dysplasia protein antibody
    • Ectodermal dysplasia, anhidrotic (hypohydrotic) antibody
    • Ectodysplasin A antibody
    • Ectodysplasin A, membrane form antibody
    • Ectodysplasin A, secreted form antibody
    • ECTODYSPLASIN A1 ISOFORM antibody
    • ECTODYSPLASIN A2 ISOFORM antibody
    • ECTODYSPLASIN antibody
    • Ectodysplasin-A antibody
    • ED1 A1 antibody
    • ED1 A2 antibody
    • ED1 antibody
    • ED1 GENE antibody
    • Eda A1 antibody
    • Eda A2 antibody
    • eda antibody
    • EDA protein antibody
    • EDA protein homolog antibody
    • EDA_HUMAN antibody
    • EDA1 antibody
    • EDA1 GENE antibody
    • EDA2 antibody
    • HED antibody
    • HED1 antibody
    • ODT1 antibody
    • Oligodontia 1 antibody
    • secreted form antibody
    • STHAGX1 antibody
    • Ta antibody
    • Tabby antibody
    • Tabby protein antibody
    • X linked anhidroitic ectodermal dysplasia protein antibody
    • XHED antibody
    • XLHED antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse embryo tissue labeling EDA with ab203075 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat placenta tissue labeling EDA with ab203075 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab203075 has not yet been referenced specifically in any publications.

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