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Anti-EDAR antibody (ab198168)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (ab198168)

    Key features and details

    • Rabbit polyclonal to EDAR
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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    Overview

    • Product name

      Anti-EDAR antibody
      See all EDAR primary antibodies
    • Description

      Rabbit polyclonal to EDAR
    • Host species

      Rabbit
    • Specificity

      This antibody detects endogenous levels of total EDAR protein.
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Synthetic peptide corresponding to Human EDAR (internal sequence).
      Database link: Q9UNE0

    • Positive control

      • Human lung cancer tissue.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.4
      Preservative: 0.05% Sodium azide
      Constituents: 49% PBS, 50% Glycerol
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • NFkB Pathway
      • Signal Transduction
      • Growth Factors/Hormones
      • TNF
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • NFkB pathway

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human EDAR protein (denatured) (ab187467)
    • Related Products

      • Recombinant Human EDAR protein (denatured) (ab187467)

    Applications

    Our Abpromise guarantee covers the use of ab198168 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/10 - 1/50.

    Target

    • Function

      Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
    • Tissue specificity

      Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
    • Involvement in disease

      Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
      Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
    • Sequence similarities

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • Developmental stage

      Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q9UNE0 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 10913 Human
      • Omim: 604095 Human
      • SwissProt: Q9UNE0 Human
      • Unigene: 171971 Human
      • Alternative names

        • Anhidrotic ectodysplasin receptor 1 antibody
        • DL antibody
        • Downless (mouse) homolog antibody
        • Downless homolog antibody
        • Downless mouse homolog of antibody
        • ECTD10A antibody
        • ECTD10B antibody
        • Ectodermal dysplasia receptor antibody
        • Ectodysplasin 1 anhidrotic receptor antibody
        • Ectodysplasin A receptor antibody
        • Ectodysplasin A1 isoform receptor antibody
        • Ectodysplasin-A receptor antibody
        • ED 1R antibody
        • ED 3 antibody
        • ED 5 antibody
        • ED1R antibody
        • ED3 antibody
        • ED5 antibody
        • EDA 1R antibody
        • EDA 3 antibody
        • EDA A1 receptor antibody
        • EDA A1R antibody
        • EDA-A1 receptor antibody
        • EDA1R antibody
        • EDA3 antibody
        • Edar antibody
        • EDAR_HUMAN antibody
        • HRM1 antibody
        • Tumor necrosis factor receptor superfamily member EDAR antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (ab198168)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (ab198168)

        Immunohistochemical analysis of paraffin-embedded human lung cancer tissue labeling EDAR with ab198168 at a 1/15 dilution.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab198168? Please let us know so that we can cite the reference in this datasheet.

      ab198168 has not yet been referenced specifically in any publications.

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