Overview

  • Product name

    Anti-EDEM2 antibody [EPR14043-24]
    See all EDEM2 primary antibodies
  • Description

    Rabbit monoclonal [EPR14043-24] to EDEM2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human EDEM2 aa 450 to the C-terminus. The exact sequence is proprietary.
    Database link: Q9BV94

  • Positive control

    • HepG2 and IM9 cell lysates.
  • General notes

     

     

     This product was previously labelled as C20orf31

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituent: 59% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR14043-24
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab180522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).

Target

  • Function

    Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
  • Tissue specificity

    Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 47 family.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Secreted. Endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA4204.1 antibody
    • C20orf31 antibody
    • C20orf49 antibody
    • EDEM 2 antibody
    • EDEM2 antibody
    • EDEM2_HUMAN antibody
    • ER degradation enhancer mannosidase alpha like 2 antibody
    • ER degradation enhancing alpha mannosidase like 2 antibody
    • ER degradation enhancing alpha mannosidase like protein 2 antibody
    • ER degradation enhancing mannosidase like protein 2 antibody
    • ER degradation-enhancing alpha-mannosidase-like 2 antibody
    • FLJ10783 antibody
    • UNQ573/PRO1135 antibody
    see all

Images

  • Anti-EDEM2 antibody [EPR14043-24] (ab180522) at 1/2000 dilution + IM9 cell lysate at 20 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 65 kDa

  • Anti-EDEM2 antibody [EPR14043-24] (ab180522) at 1/10000 dilution + HepG2 cell lysate at 20 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 65 kDa

References

ab180522 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab180522.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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