Anti-EDG2 /LPA-1 antibody (ab23698)
Key features and details
- Rabbit polyclonal to EDG2 /LPA-1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
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Overview
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Product name
Anti-EDG2 /LPA-1 antibody
See all EDG2 /LPA-1 primary antibodies -
Description
Rabbit polyclonal to EDG2 /LPA-1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human
Predicted to work with: Xenopus laevis -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- WB: Mouse liver, A549 cell lysate, Rat Liver lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab23698 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa).
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Notes |
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WB
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa). |
Target
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Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. -
Tissue specificity
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. - Information by UniProt
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Database links
- Entrez Gene: 1902 Human
- Entrez Gene: 14745 Mouse
- Entrez Gene: 116744 Rat
- Omim: 602282 Human
- SwissProt: Q92633 Human
- SwissProt: P61793 Mouse
- SwissProt: P61794 Rat
- Unigene: 126667 Human
see all -
Alternative names
- 5031439C20 antibody
- AI326300 antibody
- EDG 2 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab23698 has been referenced in 15 publications.
- Ahmadzai MM et al. LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction. J Clin Invest 132:N/A (2022). PubMed: 35166239
- Grubišić V & Gulbransen BD Astrocyte Cell Surface Antigen 2 and Other Potential Cell Surface Markers of Enteric glia in the Mouse Colon. ASN Neuro 14:17590914221083203 (2022). PubMed: 35593118
- Kim D et al. Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway. Int J Mol Sci 22:N/A (2021). PubMed: 34639115
- Lee R et al. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release. Molecules 26:N/A (2021). PubMed: 34684879
- Wu XP et al. microRNA-329 reduces bone cancer pain through the LPAR1-dependent LPAR1/ERK signal transduction pathway in mice. Ther Adv Med Oncol 11:1758835919875319 (2019). PubMed: 31692673