Key features and details
- Rabbit polyclonal to EDG2 /LPA-1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-EDG2 /LPA-1 antibody
See all EDG2 /LPA-1 primary antibodies
DescriptionRabbit polyclonal to EDG2 /LPA-1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Predicted to work with: Xenopus laevis
- WB: Mouse liver, A549 cell lysate, Rat Liver lysate.
Previously labelled as EDG2.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab23698 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa).|
FunctionReceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
Tissue specificityExpressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
- Information by UniProt
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ab23698 has been referenced in 10 publications.
- Wu XP et al. microRNA-329 reduces bone cancer pain through the LPAR1-dependent LPAR1/ERK signal transduction pathway in mice. Ther Adv Med Oncol 11:1758835919875319 (2019). PubMed: 31692673
- Wang H et al. Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1. Evid Based Complement Alternat Med 2019:2580207 (2019). PubMed: 31781264
- Cao P et al. Autocrine lysophosphatidic acid signaling activates ß-catenin and promotes lung allograft fibrosis. J Clin Invest 127:1517-1530 (2017). PubMed: 28240604
- Kajitani N et al. Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants. J Biol Chem 291:27364-27370 (2016). PubMed: 27864362
- Zhuang Y et al. MiR-338* suppresses fibrotic pathogenesis in pulmonary fibrosis through targeting LPA1. Am J Transl Res 8:3197-205 (2016). WB ; Mouse . PubMed: 27508041
- Knowlden SA et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS One 9:e101655 (2014). WB ; Mouse . PubMed: 25003200
- Ward Y et al. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene : (2012). Mouse . PubMed: 22797060
- Schneider LV et al. Method for recovery and immunoaffinity enrichment of membrane proteins illustrated with metastatic ovarian cancer tissues. Int J Proteomics 2012:838630 (2012). PubMed: 22919487
- Zhang H et al. Proteomic analysis of bone tissues of patients with osteonecrosis of the femoral head. OMICS 13:453-66 (2009). WB ; Human . PubMed: 20001860
- Liszewska E et al. Lysophosphatidic acid signaling during embryo development in sheep: involvement in prostaglandin synthesis. Endocrinology : (2008). WB, IHC-Fr ; Sheep . PubMed: 18772233