Key features and details
- Rabbit polyclonal to EDG2 /LPA-1 - Extracellular domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-EDG2 /LPA-1 antibody - Extracellular domain
See all EDG2 /LPA-1 primary antibodies
DescriptionRabbit polyclonal to EDG2 /LPA-1 - Extracellular domain
SpecificityBLAST analysis of the peptide immunogen showed no homology with other human proteins, except DDX60 (53%), ACER3 (47%).
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Hamster, Cow, Dog, Pig, Monkey, Gorilla, Bat
Synthetic peptide corresponding to Human EDG2/LPA-1 (extracellular). 15 amino acid peptide from N-terminal extracellular domain.
Database link: Q28031
- IHC-P: Human brain glia tissue.
Previously labelled as EDG2.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.099% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab219601 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionReceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
Tissue specificityExpressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
- Information by UniProt
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ab219601 has not yet been referenced specifically in any publications.