Overview

Description

  • Nature

    Synthetic
  • Amino Acid Sequence

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab184693 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking - Blocking peptide for Anti-EDG2 /LPA-1 antibody [EPR9710] (ab166903)

    • Form

      Liquid
    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

      Previously labelled as EDG2. 

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

    General Info

    • Alternative names

      • 5031439C20
      • AI326300
      • EDG 2
      • EDG2
      • Endothelial differentiation gene 2
      • Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2
      • GPCR 26
      • Gpcr26
      • Gpcr91
      • GPR26
      • Kdt2
      • LPA 1
      • LPA receptor 1
      • LPA receptor EDG2
      • LPA-1
      • lpA1
      • Lpar1
      • LPAR1_HUMAN
      • Lysophosphatidic acid receptor 1
      • Lysophosphatidic acid receptor Edg-2
      • Lysophosphatidic acid receptor EDG2
      • MGC105279
      • MGC29102
      • Mrec1.3
      • rec.1.3
      • Ventricular zone gene 1
      • vzg-1
      • VZG1
      see all
    • Function

      Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
    • Tissue specificity

      Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
    • Information by UniProt

    References

    ab184693 has not yet been referenced specifically in any publications.

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