Overview

  • Product name

  • Description

    Rabbit polyclonal to EDG3/S1P3
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NAA16 (53%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey, Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human EDG3/S1P3 (N terminal).

  • Positive control

    • Human heart tissue
  • General notes

    Previously labelled as EDG3. 

Properties

Applications

Our Abpromise guarantee covers the use of ab150573 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Proteinase K antigen retrieval is recommended.

Target

  • Function

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
  • Tissue specificity

    Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EDG 3 antibody
    • EDG3 antibody
    • Endothelial differentiation G protein coupled receptor 3 antibody
    • Endothelial differentiation G-protein coupled receptor 3 antibody
    • Endothelial differentiation gene 3 antibody
    • Endothelial differentiation sphingolipid G protein coupled receptor 3 antibody
    • FLJ37523 antibody
    • FLJ93220 antibody
    • G protein coupled receptor endothelial differentiation gene 3 antibody
    • LPB 3 antibody
    • LPB3 antibody
    • MGC71696 antibody
    • OTTHUMP00000215691 antibody
    • S1P receptor 3 antibody
    • S1P receptor Edg 3 antibody
    • S1P receptor Edg-3 antibody
    • S1P receptor EDG3 antibody
    • S1P3 antibody
    • S1pr3 antibody
    • S1PR3_HUMAN antibody
    • Sphingosine 1 phosphate receptor 3 antibody
    • Sphingosine 1 phosphate receptor Edg 3 antibody
    • Sphingosine 1 phosphate receptor Edg3 antibody
    • Sphingosine 1-phosphate receptor 3 antibody
    • Sphingosine 1-phosphate receptor Edg-3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed and paraffin embedded Human heart tissue labeling EDG3/S1P3 using ab150573 at 5ug/ml.

  • Immunohistochemical analysis of formalin fixed and paraffin embedded Human kidney tissue labeling EDG3/S1P3 using ab150573 at 5ug/ml.

References

This product has been referenced in:

  • Sun XJ  et al. Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrol Dial Transplant 32:1313-1322 (2017). Read more (PubMed: 28206609) »
  • Wang C  et al. Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues. Exp Mol Pathol 97:259-265 (2014). IHC-P ; Human . Read more (PubMed: 25084322) »
See all 2 Publications for this product

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