Overview

  • Product name

  • Description

    Rabbit polyclonal to EDG6/S1PR4
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Hamster, Cow, Pig, Monkey, Gorilla
  • Immunogen

    Synthetic peptide within Human EDG6/S1PR4 (intracellular). The exact sequence is proprietary. 20 amino acid peptide from 2nd cytoplasmic domain.
    Database link: O95977

  • Positive control

    • Recombinant Human EDG6/S1PR4 protein (ab160145) can be used as a positive control in WB. Human lymph node and Human spleen tissue.
  • General notes

     This product was previously labelled as EDG6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab188984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 9.6 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
  • Tissue specificity

    Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EDG6 antibody
    • Endothelial differentiation lysophosphatidic acid G protein coupled receptor 6 antibody
    • Endothelial differentiation G protein coupled receptor 6 antibody
    • Endothelial differentiation G-protein coupled receptor 6 antibody
    • Endothelial differentiation gene 6 antibody
    • LPC1 antibody
    • Lysophospholipid receptor C1 antibody
    • MGC129298 antibody
    • Putative G protein coupled receptor antibody
    • S1P receptor 4 antibody
    • S1P receptor Edg-6 antibody
    • S1P receptor Edg6 antibody
    • S1P4 antibody
    • S1PR4 antibody
    • S1PR4_HUMAN antibody
    • SLP4 antibody
    • Sphingosine 1 phosphate receptor 4 antibody
    • Sphingosine 1 phosphate receptor Edg6 antibody
    • Sphingosine 1-phosphate receptor 4 antibody
    • Sphingosine 1-phosphate receptor Edg-6 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling EDG6/S1PR4 with ab188984 at 9.6 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lymph node tissue labeling EDG6/S1PR4 with ab188984 at 9.6 µg/ml.

References

This product has been referenced in:

  • Palangi A  et al. Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma. Clin Transl Oncol N/A:N/A (2019). Read more (PubMed: 30712233) »
See 1 Publication for this product

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