• Product name

  • Description

    Rabbit polyclonal to EDG6/S1PR4
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow, Dog, Pig, Macaque monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human EDG6/S1PR4 aa 150-250 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab126638)

  • Positive control

    • This antibody gave a positive signal in Jurkat whole cell lysate as well as the following tissue lysates: Human Spleen; Human Tonsil; Human Lymph node.
  • General notes

     This product was previously labelled as EDG6




Our Abpromise guarantee covers the use of ab92993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 42 kDa).


  • Function

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
  • Tissue specificity

    Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EDG6 antibody
    • Endothelial differentiation lysophosphatidic acid G protein coupled receptor 6 antibody
    • Endothelial differentiation G protein coupled receptor 6 antibody
    • Endothelial differentiation G-protein coupled receptor 6 antibody
    • Endothelial differentiation gene 6 antibody
    • LPC1 antibody
    • Lysophospholipid receptor C1 antibody
    • MGC129298 antibody
    • Putative G protein coupled receptor antibody
    • S1P receptor 4 antibody
    • S1P receptor Edg-6 antibody
    • S1P receptor Edg6 antibody
    • S1P4 antibody
    • S1PR4 antibody
    • S1PR4_HUMAN antibody
    • SLP4 antibody
    • Sphingosine 1 phosphate receptor 4 antibody
    • Sphingosine 1 phosphate receptor Edg6 antibody
    • Sphingosine 1-phosphate receptor 4 antibody
    • Sphingosine 1-phosphate receptor Edg-6 antibody
    see all


  • All lanes : Anti-EDG6/S1PR4 antibody (ab92993) at 1 µg/ml

    Lane 1 : Human spleen tissue lysate - total protein (ab29699)
    Lane 2 : Tonsil (Human) Tissue Lysate
    Lane 3 : Human lymph node tissue lysate - total protein (ab29871)
    Lane 4 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 42 kDa
    Observed band size: 48 kDa
    why is the actual band size different from the predicted?
    Additional bands at: 56 kDa. We are unsure as to the identity of these extra bands.

    Exposure time: 12 minutes

    EDG6/S1PR4 contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a higher molecular weight than predicted.


ab92993 has not yet been referenced specifically in any publications.

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