Anti-LPA-3 antibody (ab219267)
Key features and details
- Rabbit polyclonal to LPA-3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-LPA-3 antibody
See all LPA-3 primary antibodies -
Description
Rabbit polyclonal to LPA-3 -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Horse, Hamster, Cow, Dog, Monkey, Gorilla, Bat -
Immunogen
Synthetic peptide corresponding to Human LPA-3. (15 amino acid peptide from 2nd cytoplasmic domain)
Database link: Q9UBY5 -
Positive control
- Human prostate carcinoma, heart myocardial infarct, brain amygdala and colon carcinoma tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.099% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab219267 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. -
Tissue specificity
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 532829 Cow
- Entrez Gene: 23566 Human
- Entrez Gene: 65086 Mouse
- Entrez Gene: 66025 Rat
- Omim: 605106 Human
- SwissProt: Q9UBY5 Human
- SwissProt: Q9EQ31 Mouse
- SwissProt: Q8K5E0 Rat
see all -
Alternative names
- Calcium mobilizing lysophosphatidic acid receptor LP A3 antibody
- Calcium mobilizing lysophosphatidic acid receptor LPA 3 antibody
- Calcium mobilizing lysophosphatidic acid receptor LPA3 antibody
see all
Images
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Prostate carcinoma tissue labeling LPA-3 with ab219267 at 4 µg/ml.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded human heart, myocardial infarct tissue labeling LPA-3 with ab219267 at 4 µg/ml.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain, amygdala tissue labeling LPA-3 with ab219267 at 4 µg/ml.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue labeling LPA-3 with ab219267 at 4 µg/ml.
Datasheets and documents
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Datasheet download
References (2)
ab219267 has been referenced in 2 publications.
- Li GC et al. Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. J Cell Physiol 234:22331-22342 (2019). PubMed: 31140597
- Zhang G et al. ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway. Mol Med Rep 17:4245-4252 (2018). PubMed: 29328374