Key features and details
- Rabbit polyclonal to EDN3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-EDN3 antibody
See all EDN3 primary antibodies
DescriptionRabbit polyclonal to EDN3
SpecificityThis antibody detects endogenous levels of total EDN3 protein.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Fusion protein within Human EDN3 (internal sequence). The exact sequence is proprietary. The identity of the protein fusion partner is GST.
Database link: P14138
- Human esophagus and thyroid cancer tissue
Previously labelled as Endothelin 3.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197374 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100.|
FunctionEndothelins are endothelium-derived vasoconstrictor peptides.
Tissue specificityExpressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
Involvement in diseaseDefects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
Sequence similaritiesBelongs to the endothelin/sarafotoxin family.
- Information by UniProt
- EDN3 antibody
- EDN3_HUMAN antibody
- Endothelin 3 antibody
ab197374 has not yet been referenced specifically in any publications.