Overview

  • Product name

  • Description

    Rabbit polyclonal to EF-Ts
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human EF-Ts (internal sequence). The exact sequence is proprietary.
    Database link: P43897

  • Positive control

    • WB: HepG2 whole cell lysate; mouse heart tissue whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • Function

    Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
  • Tissue specificity

    Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.
  • Involvement in disease

    Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:610505]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.
  • Sequence similarities

    Belongs to the EF-Ts family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • COXPD 3 antibody
    • COXPD3 antibody
    • EF TS antibody
    • EF Tsmt antibody
    • EF-Ts antibody
    • EF-TsMt antibody
    • EFTS antibody
    • EFTS_HUMAN antibody
    • EFTSMT antibody
    • Elongation factor Ts antibody
    • Elongation factor Ts mitochondrial antibody
    • HGNC12367 antibody
    • mitochondrial antibody
    • Mitochondrial elongation factor Ts antibody
    • Ts translation elongation factor mitochondrial antibody
    • TSFM antibody
    • TSMT antibody
    see all

Images

  • Anti-EF-Ts antibody (ab228491) at 1/1000 dilution + HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 35 kDa



    10% SDS-PAGE

  • Anti-EF-Ts antibody (ab228491) at 1/1000 dilution + Mouse heart tissue whole cell lysate at 50 µg

    Developed using the ECL technique.

    Predicted band size: 35 kDa



    10% SDS-PAGE

References

ab228491 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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