Efaroxan hydrochloride, alpha2 adrenoceptor and Imidazoline I1 receptor antagonist (ab145186)

Overview

  • Product name

    Efaroxan hydrochloride, alpha2 adrenoceptor and Imidazoline I1 receptor antagonist
  • Description

    Potent, highly selective α2 adrenoceptor and Imidazoline I1 receptor antagonist
  • Biological description

    Potent, highly selective α2 adrenoceptor and Imidazoline I1 receptor antagonist (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α2A, α2B, α2C, I1, and I2 receptors respectively). Shows antihyperglycemic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    89197-00-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lamkin DM  et al. a2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression. Psychoneuroendocrinology 51C:262-270 (2015). Read more (PubMed: 25462899) »
  • Lehner Z  et al. Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of a2A-adrenergic antagonism in the treatment of type 2 diabetes? Diabetologia 55:3071-82 (2012). Read more (PubMed: 22898767) »
  • Olmos G  et al. Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors. Eur J Pharmacol 262:41-8 (1994). Read more (PubMed: 7813577) »

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