Efavirenz, reverse transcriptase inhibitor (ab146822)

Overview

  • Product name

    Efavirenz, reverse transcriptase inhibitor
  • Description

    Non-nucleoside reverse transcriptase inhibitor
  • Alternative names

    • EFV
    • Sustiva
  • Biological description

    Non-nucleoside reverse transcriptase inhibitor (NNRTI). Exhibits antiviral and anticancer activities. Clinically used to treat HIV type 1 infection. Prevents RNA plus-strand initiation (IC50 = 17 nM). Induces autophagy and mitochondrial changes in neurons. Inhibits cellular proliferation and increases activation of p53 in various cancer cell lines.

  • Purity

    > 98%
  • CAS Number

    154598-52-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • Molecular weight

    315.67
  • Molecular formula

    C14H9ClF3NO2
  • PubChem identifier

    64139
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC1C#C[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F
  • Source

    Synthetic

References

ab146822 has not yet been referenced specifically in any publications.

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