Anti-EFCAB4B antibody - N-terminal (ab173705)

Overview

  • Product name
    Anti-EFCAB4B antibody - N-terminal
    See all EFCAB4B primary antibodies
  • Description
    Rabbit polyclonal to EFCAB4B - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human EFCAB4B aa 47-74 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9BSW2

  • Positive control
    • 293 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab173705 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

Target

  • Function
    Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
  • Sequence similarities
    Belongs to the EFCAB4 family.
    Contains 2 EF-hand domains.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium release-activated calcium channel regulator 2A antibody
    • CRAC channel regulator 2A antibody
    • CRACR2A antibody
    • EF hand calcium binding domain 4B antibody
    • EF hand calcium binding domain containing protein 4B antibody
    • EF-hand calcium-binding domain-containing protein 4B antibody
    • EFC4B_HUMAN antibody
    • EFCAB 4B antibody
    • Efcab4b antibody
    • FLJ33805 antibody
    • MGC4266 antibody
    see all

Images

  • Anti-EFCAB4B antibody - N-terminal (ab173705) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size: 45 kDa

References

ab173705 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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