Anti-EGFR antibody [EP38Y] (ab52894)

Rabbit monoclonal EGFR antibody [EP38Y]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 83 publication(s). Independently reviewed in 12 review(s).

Publishing research using ab52894? Please let us know so that we can cite the reference in this datasheet.

ab52894 has been referenced in 85 publications.

  • Xu Z  et al. Effects of FHIT gene on proliferation and apoptosis of osteosarcoma cells. Oncol Lett 17:877-882 (2019). PubMed: 30655842
  • Yang QC  et al. A murine model of dry eye induced by topical administration of erlotinib eye drops. Int J Mol Med 41:1427-1436 (2018). PubMed: 29286080
  • Abou-Antoun TJ  et al. Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance. PLoS One 13:e0189711 (2018). PubMed: 29298329
  • Emmerson E  et al. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med N/A:N/A (2018). PubMed: 29335337
  • Alamri AM  et al. Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing. Dis Model Mech 11:N/A (2018). PubMed: 29419396
  • Wasén C  et al. Epidermal growth factor receptor function in the human urothelium. Int Urol Nephrol 50:647-656 (2018). WB, IHC-P . PubMed: 29508172
  • Zhang Z  et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis 24:274-285 (2018). PubMed: 29643724
  • Zhang Y  et al. Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor. Sci Rep 8:5994 (2018). PubMed: 29662125
  • Yu W  et al. Prognostic value of EGFR family expression in lymph node-negative esophageal squamous cell carcinoma patients. Pathol Res Pract 214:1017-1023 (2018). IHC-P ; Human . PubMed: 29729836
  • Petrilli R  et al. Skin cancer treatment effectiveness is improved by iontophoresis of EGFR-targeted liposomes containing 5-FU compared with subcutaneous injection. J Control Release 283:151-162 (2018). WB . PubMed: 29864476
  • Kang M  et al. Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA. J Exp Clin Cancer Res 37:171 (2018). PubMed: 30049286
  • Wang SL  et al. Prognostic significance of the expression of HER family members in primary osteosarcoma. Oncol Lett 16:2185-2194 (2018). PubMed: 30008917
  • MacDonald E  et al. HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion. J Cell Biol 217:2549-2564 (2018). PubMed: 29891722
  • Fu H  et al. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Mol Ther Nucleic Acids 12:769-786 (2018). PubMed: 30141410
  • Qu X  et al. Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR. Pathol Res Pract 214:1974-1979 (2018). PubMed: 30262429
  • Lee SK  et al. A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab. Exp Mol Med 50:153 (2018). PubMed: 30459318
  • Zhu T  et al. LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression. J Cell Mol Med N/A:N/A (2018). PubMed: 30515972
  • Tang LR  et al. Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1a. Onco Targets Ther 11:8507-8515 (2018). PubMed: 30555241
  • Yang Q  et al. Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development. Front Mol Neurosci 11:447 (2018). PubMed: 30574069
  • Albishtue AA  et al. Effects of EBN on embryo implantation, plasma concentrations of reproductive hormones, and uterine expressions of genes of PCNA, steroids, growth factors and their receptors in rats. Theriogenology 126:310-319 (2018). PubMed: 30605790
  • Xie YP  et al. CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy. Theranostics 8:5995-6007 (2018). PubMed: 30613277
  • Elliott JT  et al. Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma. Clin Cancer Res 23:2203-2212 (2017). PubMed: 27799250
  • Tavares LA  et al. CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the ?1 and ?2 subunits of the AP-1 complex in protein trafficking. J Cell Sci 130:429-443 (2017). PubMed: 27909244
  • Sato Y  et al. Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells. Oncotarget 8:39345-39355 (2017). PubMed: 28454117
  • Tripathi SC  et al. MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway. Cancer Res 77:4414-4425 (2017). PubMed: 28646020
  • Li S  et al. Ectodysplasin A protein promotes corneal epithelial cell proliferation. J Biol Chem 292:13391-13401 (2017). PubMed: 28655773
  • Bombardo M  et al. Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia. Br J Pharmacol 174:3865-3880 (2017). PubMed: 28832971
  • Minutti CM  et al. Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity 47:710-722.e6 (2017). PubMed: 29045902
  • Evans AJ  et al. Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity. Cell Rep 19:2613-2626 (2017). WB . PubMed: 28636947
  • Zhuang L  et al. MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma. J Cell Mol Med 21:2852-2862 (2017). PubMed: 28653805
  • Fontana AO  et al. Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence. J Neurooncol 133:497-507 (2017). PubMed: 28500562
  • Oldrini B  et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun 8:2035 (2017). ICC/IF ; Human . PubMed: 29229958
  • Petersen I  et al. EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®). Pathol Res Pract 213:1530-1535 (2017). PubMed: 29108919
  • Chen YC  et al. Laser-emission imaging of nuclear biomarkers for high-contrast cancer screening and immunodiagnosis. Nat Biomed Eng 1:724-735 (2017). IHC ; Human . PubMed: 29204310
  • Williams V  et al. Detection of IKKe by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis. BMC Cancer 17:356 (2017). PubMed: 28532474
  • Chen J  et al. A role for ErbB signaling in the induction of reactive astrogliosis. Cell Discov 3:17044 (2017). PubMed: 29238610
  • Xu T  et al. Oridonin enhancesin vitroanticancer effects of lentinan in SMMC-7721 human hepatoma cells through apoptotic genes. Exp Ther Med 14:5129-5134 (2017). PubMed: 29201227
  • Huang XY  et al. Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma. Oncotarget 8:95450-95465 (2017). PubMed: 29221140
  • Hsu PY  et al. Cordycepin and a preparation fromCordyceps militarisinhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model. Oncotarget 8:93712-93728 (2017). PubMed: 29212184
  • Rübsam M  et al. E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Nat Commun 8:1250 (2017). PubMed: 29093447
  • Li H  et al. RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR. Oncotarget 8:72633-72651 (2017). PubMed: 29069815
  • Ran H  et al. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A 114:4816-4821 (2017). PubMed: 28424251
  • Cheng Z  et al. MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression. Oncotarget 8:46312-46325 (2017). PubMed: 28564633
  • Mehner C  et al. EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review. Genes Cancer 8:589-599 (2017). PubMed: 28740577
  • Yang HK  et al. Downregulation of LRIG2 expression inhibits angiogenesis of glioma via EGFR/VEGF-A pathway. Oncol Lett 14:4021-4028 (2017). PubMed: 28943909
  • Liang J  et al. Epstein-Barr virus-encoded LMP2A stimulates migration of nasopharyngeal carcinoma cells via the EGFR/Ca(2+)/calpain/ITGß4 axis. Biol Open 6:914-922 (2017). PubMed: 28512118
  • Emmerson E  et al. SOX2 regulates acinar cell development in the salivary gland. Elife 6:N/A (2017). ICC/IF ; Mouse, Human . PubMed: 28623666
  • Guan G  et al. Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells. Tumour Biol 39:1010428317691740 (2017). PubMed: 28347232
  • Tang H  et al. Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nat Commun 8:14909 (2017). IHC . PubMed: 28416796
  • Kankia IH  et al. NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib. Oxid Med Cell Longev 2017:1864578 (2017). PubMed: 29410730
  • de Souza AL  et al. Fluorescent Affibody Molecule Administered In Vivo at a Microdose Level Labels EGFR Expressing Glioma Tumor Regions. Mol Imaging Biol 19:41-48 (2017). PubMed: 27379987
  • Iida M  et al. Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab. Mol Cancer Ther 15:2175-86 (2016). PubMed: 27422810
  • Hessmann E  et al. NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation. Stem Cells Int 2016:5272498 (2016). IHC . PubMed: 26697077
  • He F  et al. Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS. Oncotarget 7:37000-37012 (2016). WB . PubMed: 27203742
  • Derangère V  et al. Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer? Oncotarget 7:9309-21 (2016). WB . PubMed: 26824184
  • Chen CC  et al. The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene 35:1314-23 (2016). WB . PubMed: 26028023
  • Wang G  et al. Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPAR? signalling pathway. Sci Rep 6:35783 (2016). WB . PubMed: 27779188
  • Ambrogio C  et al. In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma. Oncogene N/A:N/A (2016). PubMed: 27775074
  • Jaako K  et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci 129:3792-3802 (2016). PubMed: 27566163
  • Zhang Y  et al. Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC. Oncol Lett 12:3241-3249 (2016). IHC-P ; Mouse . PubMed: 27899989
  • Xu J  et al. HER2 overexpression reverses the relative resistance of EGFR-mutant H1975 cell line to gefitinib. Oncol Lett 12:5363-5369 (2016). WB ; Human . PubMed: 28105244
  • Wang J  et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun 7:11795 (2016). IHC . PubMed: 27273304
  • Wang Z  et al. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncol Rep 36:589-97 (2016). PubMed: 27221381
  • Bo T  et al. Characterization of a Relatively Malignant Form of Osteopetrosis Caused by a Novel Mutation in the PLEKHM1 Gene. J Bone Miner Res 31:1979-1987 (2016). PubMed: 27291868
  • Zhang H  et al. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/ß-Catenin Signaling. Cell Physiol Biochem 39:360-70 (2016). PubMed: 27352380
  • Lu YY  et al. 1118-20, an indazole diarylurea compound, inhibits hepatocellular carcinoma HepG2 proliferation and tumour angiogenesis involving Wnt/ß-catenin pathway and receptor tyrosine kinases. J Pharm Pharmacol 67:1393-405 (2015). WB ; Human . PubMed: 26076716
  • Fu Y  et al. Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype. Sci Rep 5:13347 (2015). PubMed: 26289340
  • Mehner C  et al. Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers. Oncotarget 6:35737-54 (2015). WB . PubMed: 26437224
  • Sethi MK  et al. In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation. Glycobiology 25:1064-78 (2015). PubMed: 26085185
  • Shuai S  et al. TIP30 nuclear translocation negatively regulates EGF-dependent cyclin D1 transcription in human lung adenocarcinoma. Cancer Lett 354:200-9 (2014). PubMed: 25135222
  • Samkoe KS  et al. Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach. Cancer Res 74:7465-74 (2014). PubMed: 25344226
  • Brand TM  et al. Nuclear epidermal growth factor receptor is a functional molecular target in triple-negative breast cancer. Mol Cancer Ther 13:1356-68 (2014). PubMed: 24634415
  • Iida M  et al. Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab. Neoplasia 15:1196-206 (2013). PubMed: 24204198
  • Brand TM  et al. Mapping C-terminal transactivation domains of the nuclear HER family receptor tyrosine kinase HER3. PLoS One 8:e71518 (2013). WB ; Human . PubMed: 23951180
  • Sollome JJ  et al. HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal 26:70-82 (2013). Human . PubMed: 24036211
  • de Castro CV  et al. Tyrosine kinase receptor expression in chordomas: phosphorylated AKT correlates inversely with outcome. Hum Pathol 44:1747-55 (2013). ICC/IF ; Human . PubMed: 23618355
  • Yuan Y  et al. Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways. Biochim Biophys Acta 1830:4907-16 (2013). PubMed: 23850473
  • Giles KM  et al. Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib. Mol Cancer Ther 12:2541-58 (2013). WB ; Human . PubMed: 24026012
  • Clark PA  et al. Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia 14:420-8 (2012). IF . PubMed: 22745588
  • Modena P  et al. Predictors of outcome in an AIEOP series of childhood ependymomas: a multifactorial analysis. Neuro Oncol 14:1346-56 (2012). IHC ; Human . PubMed: 23076205
  • Raina D  et al. Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells. Mol Cancer Ther 10:806-16 (2011). IP ; Human . PubMed: 21421804
  • Burga LN  et al. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res 13:R30 (2011). WB, ICC/IF ; Human . PubMed: 21396117
  • Bade LK  et al. Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor. J Cell Sci 124:3106-17 (2011). WB ; Mouse . PubMed: 21868365
  • Choi KY  et al. Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proc Natl Acad Sci U S A 108:15219-24 (2011). WB ; Mouse . PubMed: 21896768
  • Restivo G  et al. IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J 30:4571-85 (2011). PubMed: 21909072

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