Overview

  • Product name

    EHNA hydrochloride, PDE2 inhibitor
  • Description

    Selective PDE2 inhibitor. Potent adenosine deaminase inhibitor.
  • Biological description

    Selective PDE2 inhibitor (IC50 values are 0.8 and 4 μM for human and porcine PDE2 respectively). Potent adenosine deaminase inhibitor. Shows antidifferentiation effects. Stimulates apoptosis. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    51350-19-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bernard JJ  et al. PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis. PLoS One 9:e109862 (2014). Read more (PubMed: 25330380) »
  • Burton P  et al. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochem J 432:575-84 (2010). Read more (PubMed: 20923411) »
  • Woodson JC  et al. Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats. Behav Neurosci 112:399-409 (1998). Read more (PubMed: 9588486) »

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