• Product name
    Anti-eIF2B epsilon antibody
    See all eIF2B epsilon primary antibodies
  • Description
    Rabbit polyclonal to eIF2B epsilon
  • Host species
  • Tested applications
    Suitable for: IHC-P, IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 550-600 (IKVFQNEVLG TLQRGKEENI SCDNLVLEIN SLKYAYNISL KEVMQVLSHV V) of Human eIF2B epsilon (NP_003898.2).

  • Positive control
    • HeLa whole cell lysate



Our Abpromise guarantee covers the use of ab91563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use at 5-15 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
    • Involvement in disease
      Defects in EIF2B5 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
    • Sequence similarities
      Belongs to the eIF-2B gamma/epsilon subunits family.
      Contains 1 W2 domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • CACH antibody
      • CLE antibody
      • EI2BE_HUMAN antibody
      • EIF 2B antibody
      • eIF 2B GDP GTP exchange factor antibody
      • eIF 2B GDP GTP exchange factor subunit epsilon antibody
      • eIF-2B GDP-GTP exchange factor subunit epsilon antibody
      • EIF2B antibody
      • EIF2B5 antibody
      • EIF2BE antibody
      • EIF2Bepsilon antibody
      • Eukaryotic Translation Initiation Factor 2 Beta Epsilon antibody
      • Eukaryotic translation initiation factor 2B subunit 5 epsilon 82kDa antibody
      • Eukaryotic translation initiation factor 2B subunit 5 epsilon antibody
      • LVWM antibody
      • Translation initiation factor eIF 2B subunit epsilon antibody
      • Translation initiation factor eIF-2B subunit epsilon antibody
      see all


    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling eIF2B epsilon with ab91563 at 1/1000 (1µg/ml). Detection: DAB.
    • ab91563 at 10 µg/mg lysate precipitating eIF2b epsilon in HeLa whole cell lysate following IP. Lane 1; IP with an antibody which recognizes an upstream epitope of eIF2b epsilon. Lane 2; IP with ab91563. Lane 3; control IgG. In each case, 1 mg of lysate was used for IP and 20% of the IP was loaded. Detection by WB utilised the ECL with a 10 second exposure.


    ab91563 has not yet been referenced specifically in any publications.

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