Overview

  • Product name
  • Description
    Mouse polyclonal to EIF3C
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Cow, Orangutan
  • Immunogen

    Recombinant full length protein corresponding to Human EIF3C aa 1-913.
    Database link: NP_003743.1

  • Positive control
    • WB: U-2 OS, Raw 264.7 and EIF3C transfected 293T cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab167635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 105 kDa.

Target

  • Function
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
  • Sequence similarities
    Belongs to the eIF-3 subunit C family.
    Contains 1 PCI domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cell migration inducing protein 17 antibody
    • eIF 3c antibody
    • eIF3 p110 antibody
    • eIF3-p110 antibody
    • eIF3c antibody
    • EIF3C_HUMAN antibody
    • EIF3CL antibody
    • EIF3S8 antibody
    • EIF3S8 protein antibody
    • Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody
    • Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody
    • Eukaryotic translation initiation factor 3 subunit 8 antibody
    • Eukaryotic translation initiation factor 3 subunit C antibody
    see all

Images

  • Anti-EIF3C antibody (ab167635) at 1/500 dilution + U-2 OS at 50 µg

    Predicted band size: 105 kDa

  • Anti-EIF3C antibody (ab167635) at 1/500 dilution + Raw 264.7 at 50 µg

    Predicted band size: 105 kDa

  • All lanes : Anti-EIF3C antibody (ab167635) at 1/500 dilution

    Lane 1 : EIF3C transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 15 µl per lane.

    Predicted band size: 105 kDa

References

ab167635 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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