Overview

  • Product name

    Anti-EIF3S1/EIF3J antibody
    See all EIF3S1/EIF3J primary antibodies
  • Description

    Rabbit polyclonal to EIF3S1/EIF3J
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Chicken, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human EIF3S1/EIF3J (internal sequence). The exact sequence is proprietary.
    Database link: O75822

  • Positive control

    • WB: Raji whole cell lysate.
  • General notes

     This product was previously labelled as EIF3S1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab228931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 29 kDa.

Target

  • Function

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
  • Sequence similarities

    Belongs to the eIF-3 subunit J family.
  • Post-translational
    modifications

    Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • eIF 3 alpha antibody
    • eIF-3-alpha antibody
    • eIF3 alpha antibody
    • eIF3 p35 antibody
    • eIF3j antibody
    • EIF3J_HUMAN antibody
    • EIF3S 1 antibody
    • EIF3S1 antibody
    • Eukaryotic translation initiation factor 3 subunit 1 antibody
    • Eukaryotic translation initiation factor 3 subunit J antibody
    • Eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD) antibody
    • Eukaryotic translation initiation factor 3, subunit 1 alpha, 35kD antibody
    see all

Images

  • Anti-EIF3S1/EIF3J antibody (ab228931) at 1/1000 dilution + Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 29 kDa



    12% SDS-PAGE

References

ab228931 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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