Overview

  • Product name

    Anti-ELAC2 antibody - C-terminal
    See all ELAC2 primary antibodies
  • Description

    Rabbit polyclonal to ELAC2 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Fusion protein corresponding to Human ELAC2 (C terminal). (Residues near the C terminus.) The identity of the protein fusion partner is GST. Gene Accssion: BC001939
    Database link: Q9BQ52

  • Positive control

    • Hela and Lovo cell lysates; Human gastric cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 92 kDa.

Target

  • Function

    Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
  • Tissue specificity

    Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
  • Involvement in disease

    Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • Sequence similarities

    Belongs to the RNase Z family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • COXPD17 antibody
    • elaC homolog 2 (E. coli) antibody
    • ElaC homolog protein 2 antibody
    • elaC ribonuclease Z 2 antibody
    • elaC, E. coli, homolog of, 2 antibody
    • ELAC2 antibody
    • ELC2 antibody
    • FLJ10530 antibody
    • FLJ36693 antibody
    • FLJ42848 antibody
    • Heredity prostate cancer protein 2 antibody
    • HPC2 antibody
    • putative prostate cancer susceptibility protein HPC2/ELAC2 antibody
    • Ribonuclease Z 2 antibody
    • Ribonuclease Z, long form antibody
    • Ribonuclease Z2 antibody
    • RNase Z 2 antibody
    • RNase Z2 antibody
    • RNase ZL antibody
    • RNZ2_HUMAN antibody
    • tRNA 3 endonuclease 2 antibody
    • tRNase Z (long form) antibody
    • tRNase Z 2 antibody
    • tRNase Z2 antibody
    • Zinc phosphodiesterase ELAC protein 2 antibody
    see all

Images

  • All lanes : Anti-ELAC2 antibody - C-terminal (ab197944) at 1/250 dilution

    Lane 1 : Lovo cell lysate
    Lane 2 : Hela cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 92 kDa


    Exposure time: 1 minute


    6% SDS PAGE

  • Immunohistochemical analysis of formalin fixed paraffin embedded Human gastric cancer tissue labeling ELAC2 with ab197944 at a 1/30 dilution.

References

ab197944 has not yet been referenced specifically in any publications.

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