Key features and details
- Rabbit polyclonal to Elf4/MEF
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Elf4/MEF antibody
See all Elf4/MEF primary antibodies
DescriptionRabbit polyclonal to Elf4/MEF
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human Elf4/MEF aa 1-200.
MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYS GLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLN MESPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDT SDQEGHSLEEKASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKK
Database link: Q99607
- IHC-P: Human breast cancer, prostate, and colon cancer tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab238573 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
FunctionTranscriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway.
Tissue specificityAbundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
Involvement in diseaseA chromosomal aberration involving ELF4 is a cause of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.
Sequence similaritiesBelongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Cellular localizationNucleus > PML body. Accumulation into PML nuclear bodies is mediated by PML.
- Information by UniProt
- E74-like factor 4 antibody
- ELF4 antibody
- ELF4_HUMAN antibody
Paraffin-embedded human breast cancer tissue stained for Elf4/MEF using ab238573 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human prostate tissue stained for Elf4/MEF using ab238573 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human colon cancer tissue stained for Elf4/MEF using ab238573 at 1/100 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab238573 has not yet been referenced specifically in any publications.