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RecombinantRabMAb

Recombinant Anti-ELOVL2 antibody [EPR11880] (ab176327)

  • Datasheet
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Immunoprecipitation - Anti-ELOVL2 antibody [EPR11880] (ab176327)
  • Western blot - Anti-ELOVL2 antibody [EPR11880] (ab176327)
  • Anti-ELOVL2 antibody [EPR11880] (ab176327)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR11880] to ELOVL2
  • Suitable for: IP, WB
  • Reacts with: Mouse, Rat, Human

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Overview

  • Product name

    Anti-ELOVL2 antibody [EPR11880]
    See all ELOVL2 primary antibodies
  • Description

    Rabbit monoclonal [EPR11880] to ELOVL2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IP, WBmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human ELOVL2 aa 250 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
    Database link: Q9NXB9

  • Positive control

    • Rat liver, Mouse testis, Fetal liver and Mouse liver lysates
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR11880
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Lipids / Lipoproteins
    • Fatty Acids
    • Synthesis
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Cardiovascular
    • Atherosclerosis
    • Diabetes associated
    • Metabolism
    • Types of disease
    • Diabetes
    • Metabolism
    • Types of disease
    • Heart disease
    • Metabolism
    • Pathways and Processes
    • Redox metabolism
    • Fatty acid oxidation

Associated products

  • Alternative Versions

    • Anti-ELOVL2 antibody [EPR11880] - BSA and Azide free (ab249907)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Positive Controls

    • Mouse testis normal tissue lysate - total protein (ab29289)
    • Mouse liver tissue lysate - total protein (ab29301)
  • Recombinant Protein

    • Recombinant Human ELOVL2 protein (ab162883)
  • Related Products

    • Recombinant Human ELOVL2 protein (ab162883)

Applications

Our Abpromise guarantee covers the use of ab176327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/10 - 1/100.
WB 1/1000 - 1/10000. Predicted molecular weight: 34 kDa.
  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function

      Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA.
    • Tissue specificity

      Liver and testis.
    • Sequence similarities

      Belongs to the ELO family.
    • Domain

      The di-lysine motif may confer endoplasmic reticulum localization.
    • Cellular localization

      Endoplasmic reticulum membrane.
    • Target information above from: UniProt accession Q9NXB9 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 54898 Human
      • Entrez Gene: 54326 Mouse
      • Entrez Gene: 498728 Rat
      • Omim: 611814 Human
      • SwissProt: Q9NXB9 Human
      • SwissProt: Q9JLJ4 Mouse
      • Unigene: 656436 Human
      • Unigene: 2567 Mouse
      • Alternative names

        • 3 keto acyl CoA synthase ELOVL2 antibody
        • 3-keto acyl-CoA synthase Elovl2 antibody
        • Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast) like 2 antibody
        • Elongation of very long chain fatty acids protein 2 antibody
        • ELOV2_HUMAN antibody
        • ELOVL fatty acid elongase 2 antibody
        • Elovl2 antibody
        • FLJ20334 antibody
        • OTTHUMP00000016029 antibody
        • SSC2 antibody
        see all

      Images

      • Immunoprecipitation - Anti-ELOVL2 antibody [EPR11880] (ab176327)
        Immunoprecipitation - Anti-ELOVL2 antibody [EPR11880] (ab176327)

        Western blot analysis on immunoprecipitation pellet from mouse liver lysate labeling ELOVL2 using ab176327 at a 1/10 dilution.

      • Western blot - Anti-ELOVL2 antibody [EPR11880] (ab176327)
        Western blot - Anti-ELOVL2 antibody [EPR11880] (ab176327)
        All lanes : Anti-ELOVL2 antibody [EPR11880] (ab176327) at 1/1000 dilution

        Lane 1 : Rat liver lysate
        Lane 2 : Mouse testis lysate
        Lane 3 : Fetal liver lysate
        Lane 4 : Mouse liver lysate

        Lysates/proteins at 10 µg per lane.

        Predicted band size: 34 kDa

      • Anti-ELOVL2 antibody [EPR11880] (ab176327)
        Anti-ELOVL2 antibody [EPR11880] (ab176327)

      Protocols

      • Western blot protocols
      • Immunoprecipitation protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (4)

      Publishing research using ab176327? Please let us know so that we can cite the reference in this datasheet.

      ab176327 has been referenced in 4 publications.

      • Sarr O  et al. Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency. J Nutr Biochem 63:140-149 (2019). PubMed: 30368227
      • Ding Y  et al. MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2. J Exp Clin Cancer Res 38:498 (2019). PubMed: 31856871
      • Song L  et al. Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. Sci Rep 7:41604 (2017). WB ; Rat . PubMed: 28169366
      • Yan M  et al. Identification of SPOP related metabolic pathways in prostate cancer. Oncotarget 8:103032-103046 (2017). WB . PubMed: 29262542

      Customer reviews and Q&As

      Show All Reviews Q&A
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      There are currently no Customer reviews or Questions for ab176327.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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