Our Abpromise guarantee covers the use of ab14924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 37.7 kDa.


  • Function

    Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps.
  • Tissue specificity

    Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no espression in heart, lung, liver, or leukocates.
  • Involvement in disease

    Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3) [MIM:600110]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the ELO family.
  • Domain

    The di-lysine motif may confer endoplasmic reticulum localization.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3-keto acyl-CoA synthase ELOVL4 antibody
    • ADMD antibody
    • Cancer/testis antigen 118 antibody
    • CT118 antibody
    • Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 4 antibody
    • Elongation of very long chain fatty acids like 4 antibody
    • Elongation of very long chain fatty acids protein 4 antibody
    • ELOV L4 antibody
    • ELOV4_HUMAN antibody
    • ELOVL 4 antibody
    • ELOVL4 antibody
    • FLJ17667 antibody
    • FLJ92876 antibody
    • Stargardt disease 3 antibody
    • Stargardt disease 3 autosomal dominant antibody
    • STGD 2 antibody
    • STGD 3 antibody
    • STGD2 antibody
    • STGD3 antibody
    see all


This product has been referenced in:

  • Raz-Prag D  et al. Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Invest Ophthalmol Vis Sci 47:3603-11 (2006). Read more (PubMed: 16877435) »
See 1 Publication for this product

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