Overview

  • Product name
  • Description
    Rabbit polyclonal to ELP2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to Human ELP2 aa 318-620 (internal sequence).
    Database link: Q6IA86

  • Positive control
    • HeLa nuclear cell lysate. HeLa cells. Human colon carcinoma tissue.
  • General notes

    Previously labelled as STATIP1.

Properties

Applications

Our Abpromise guarantee covers the use of ab154643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternatively Tris-EDTA buffer (pH8.0) may be used.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Regulates the ligand-dependent activation of STAT3.
    Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
  • Sequence similarities
    Belongs to the WD repeat ELP2 family.
    Contains 14 WD repeats.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AU023723 antibody
    • Elongation protein 2 homolog (S. cerevisiae) antibody
    • Elongator acetyltransferase complex subunit 2 antibody
    • Elongator complex protein 2 antibody
    • elongator protein 2 antibody
    • ELP2 antibody
    • ELP2_HUMAN antibody
    • Epl2 antibody
    • FLJ10879 antibody
    • SHINC 2 antibody
    • SHINC-2 antibody
    • SHINC2 antibody
    • signal transducer and activator of transcription 3 interacting protein 1 antibody
    • signal transducer and activator of transcription interacting protein 1 antibody
    • STAT3 interacting protein 1 antibody
    • Stat3 interacting protein antibody
    • STAT3-interacting protein 1 antibody
    • STATIP 1 antibody
    • STATIP1 antibody
    • STATIP1 protein antibody
    • StIP antibody
    • StIP1 antibody
    see all

Images

  • Anti-ELP2 antibody (ab154643) at 1/1000 dilution + HeLa nuclear lysate at 20 µg

    Predicted band size: 93 kDa



    7.5% SDS PAGE
  • Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling ELP2 with ab154643 at a 1/500 dilution. Alpha-tubulin filaments were labeled red at 1/2000.

  • Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue labelling ELP2 with ab154643 at a 1/250 dilution.

References

This product has been referenced in:
  • Hogstrand C  et al. A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). Biochem J 455:229-37 (2013). Read more (PubMed: 23919497) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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