Embelin, cell-permeable inhibitor of X-linked inhibitor of apoptosis (ab141061)

Overview

  • Product name

    Embelin, cell-permeable inhibitor of X-linked inhibitor of apoptosis
  • Description

    Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis
  • Biological description

    Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM). Binds to the XIAP BIR3 protein and interacts with residues crucial for Smac and caspsase-9 binding. Inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells (IC50 = 3.7 - 5.7 μM); minimal effects on normal prostate cells (IC50 = 19.3 - 20.1 μM). Antitumor and anti-inflammatory effects in vivo.
  • Purity

    > 98%
  • CAS Number

    550-24-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kim SW  et al. Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades. Prostate : (2012). Read more (PubMed: 22887478) »
  • Kalyan Kumar G  et al. Embelin reduces cutaneous TNF-a level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. Eur J Pharmacol 662:63-9 (2011). Read more (PubMed: 21549694) »
  • Nikolovska-Coleska Z  et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 47:2430-40 (2004). Read more (PubMed: 15115387) »

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