Overview

  • Product name

    Anti-EMR2 antibody - N-terminal
    See all EMR2 primary antibodies
  • Description

    Rabbit polyclonal to EMR2 - N-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey, Gorilla
  • Immunogen

    A 20 amino acid synthetic peptide corresponding to the N-terminal extracellular domain of Human EMR2 (NP_038475.2).

  • Positive control

    • Human lung, pneumonia, neutrophils tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab150481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 14 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor probably involved in cell attachment.
  • Tissue specificity

    Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 5 EGF-like domains.
    Contains 1 GPS domain.
  • Domain

    The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
    Binding to chondroitin sulfate is mediated by the fourth EGF domain.
  • Post-translational
    modifications

    Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD 312 antibody
    • CD 312 antigen antibody
    • CD312 antibody
    • CD312 antigen antibody
    • Egf like module containing mucin like hormone receptor like 2 antibody
    • Egf like module containing mucin like hormone receptor like sequence 2 antibody
    • EGF like module EMR2 antibody
    • EGF-like module receptor 2 antibody
    • EGF-like module-containing mucin-like hormone receptor-like 2 antibody
    • EMR2 antibody
    • EMR2_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human lung, pneumonia, neutrophils tissue labelling EMR2 with ab150481 antibody at a concentration of 14 µg/ml.

References

ab150481 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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