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Cxcl1
Function
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Post-translational modifications
N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Sequence similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Cellular localization
- Secreted
Alternative names
- Growth-regulated alpha protein
- C-X-C motif chemokine 1
- GRO-alpha(1-73)
- Melanoma growth stimulatory activity
- Neutrophil-activating protein 3
- MGSA
- NAP-3
- MGSA
- GROA
- SCYB1
- GRO1
- GRO
- CXCL1
Database links
Target type
Proteins
Primary research area
Immunology & Infectious Disease
Other research areas
- Immuno-oncology
- Neuroscience
Molecular weight
11301Da