AB193655

Human Angiogenesis Antibody Array - Membrane (43 Targets)

Name: Human Angiogenesis Antibody Array - Membrane (43 Targets) (ab193655) | Abcam
Brand: Abcam Limited
SKU: AB193655
Price: 955 USD
Availability: InStock

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(15 Publications)

Human Angiogenesis Antibody Array - Membrane (43 Targets) ab193655 is a membrane based multiplex immunoassay for the simultaneous detection of 43 angiogenic factors in all liquid sample types.

- More data, less sample: screen multiple angiogenic factors with the same sample
- Global view of angiogenesis
- Chemiluminescent detection - no specific equipment required
- Highly sensitive (pg/mL)

View Alternative Names

RNASE5, ANG, Angiogenin, Ribonuclease 5, RNase 5

1 Images

Multiplex Protein Detection - Human Angiogenesis Antibody Array - Membrane (43 Targets) (AB193655)

Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human Angiogenesis Antibody Array - Membrane (43 Targets) (AB193655)

Typical images obtained with Abcam Human Angiogenesis Antibody Array - Membrane C2 (43 Targets) ab193655. These membranes were probed with conditioned media from two different cell lines. Membranes were exposed to film at room temperature for 1 minute.

Key facts

Assay type

Semi-quantitative

Reacts with

Human

Target

ANG

target

Applications

Multiplex Protein Detection

applications

Detection method

Luminescent

Assay Platform

Microplate

Sample types

Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Multiplex Protein Detection": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Product details

ab193655 can be used for simultaneous detection of 43 Human Angiogenesis proteins in serum, plasma, cell culture media and other liquid sample types. It comes as 1 kit including 2 separate membranes labelled C1 and C2 (see below for images showing the array layout on each membrane).

Targets: Angiogenin, Angiopoietin-1, Angiopoietin-2, Angiostatin, bFGF, EGF, ENA-78 (CXCL5), Endostatin, GCSF, GM-CSF, GRO alpha, GRO beta, GRO gamma, I-309 (TCA-3/CCL1), IFN-gamma, IGF-1, IL-10, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, IL-6, IL-8 (CXCL8), I-TAC (CXCL11), Leptin, MCP-1 (CCL2), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PDGF-BB, PECAM-1 (CD31), PLGF, RANTES (CCL5), TGF beta 1, Thrombopoietin (TPO), Tie-2,TIMP-1, TIMP-2, TNF alpha, uPAR, VEGF-A, VEGFR2, VEGFR3, VEGF-D.

If you are interested in this cytokine array, arrays ab133998, ab133997, ab134000, ab169808 and ab169804 may also be of interest. A list of human antibody membrane arrays is available here.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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What's included?

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Properties and storage information

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

-20°C

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Product protocols

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Target data

Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed : 12051708, PubMed : 1400510, PubMed : 19332886, PubMed : 20129916, PubMed : 21855800, PubMed : 23047679, PubMed : 23843625, PubMed : 2424496, PubMed : 2459697, PubMed : 2730651, PubMed : 27518564, PubMed : 28176817, PubMed : 29100074, PubMed : 29748193, PubMed : 3122207, PubMed : 32510170, PubMed : 38718836, PubMed : 8159680, PubMed : 8570639, PubMed : 8622921, PubMed : 9578571). Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus (PubMed : 29100074, PubMed : 32510170). Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs) : specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (PubMed : 1400510, PubMed : 19332886, PubMed : 20129916, PubMed : 21855800, PubMed : 23047679, PubMed : 27518564, PubMed : 29100074, PubMed : 29748193, PubMed : 32510170, PubMed : 38718836). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (By similarity). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36 (PubMed : 3289612, PubMed : 38718836). Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec) (PubMed : 31582561). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation (PubMed : 12051708, PubMed : 15735021, PubMed : 27518564, PubMed : 29100074, PubMed : 8127865). Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (PubMed : 19354288, PubMed : 4074709, PubMed : 8448182). Involved in hematopoietic stem and progenitor cell (HSPC) growth and survival by promoting rRNA transcription in growth conditions and inhibiting translation in response to stress, respectively (PubMed : 27518564). Mediates the crosstalk between myeloid and intestinal epithelial cells to protect the intestinal epithelial barrier integrity : secreted by myeloid cells and promotes intestinal epithelial cells proliferation and survival (PubMed : 32510170). Also mediates osteoclast-endothelial cell crosstalk in growing bone : produced by osteoclasts and protects the neighboring vascular cells against senescence by promoting rRNA transcription (By similarity).

See full target information ANG

Additional targets

ANGPT1,ANGPT2,PLG,FGF2,CXCL5,EGF,COL18A1,CSF3,CSF2,CXCL3,CCL1,IFNG,IGF1,IL1A,IL1B,IL10,IL2,IL4,IL6,CXCL8,CXCL11,LEP,CCL2,CCL7,CCL13,MMP1,PDGFB,PECAM1,PGF,CCL5,TGFB1,THPO,TEK,TIMP1,TIMP2,TNF,PLAUR,VEGFA,VEGFD,KDR,FLT4

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40429902

2025

Silver Nanoparticles at Low Concentrations Embedded in ECM Promote Endothelial Monolayer Formation and Cell Migration.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara Wójcik,Katarzyna Zawadzka,Anna Hotowy,Maria Jóźwiak,Klaudia Jusińska,Mateusz Wierzbicki

Cancers 16: PubMed39272901

2024

The RAL Small G Proteins Are Clinically Relevant Targets in Triple Negative Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

David Han,Jonathan M Spehar,Dillon S Richardson,Sumudu Leelananda,Prathik Chakravarthy,Samantha Grecco,Jesse Reardon,Daniel G Stover,Chad Bennett,Gina M Sizemore,Zaibo Li,Steffen Lindert,Steven T Sizemore

International journal of molecular sciences 24: PubMed37762073

2023

The Inhibition of the FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriela Morales-Guadarrama,Edgar A Méndez-Pérez,Janice García-Quiroz,Euclides Avila,María J Ibarra-Sánchez,José Esparza-López,Rocío García-Becerra,Fernando Larrea,Lorenza Díaz

Stem cell research & therapy 14:193 PubMed37533021

2023

Hybrid spheroids containing mesenchymal stem cells promote therapeutic angiogenesis by increasing engraftment of co-transplanted endothelial colony-forming cells in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Young Cheol Song,Gyu Tae Park,Hye Ji Moon,Eun-Bae Choi,Mi-Ju Lim,Jung Won Yoon,Nayeon Lee,Sang Mo Kwon,Byung-Joo Lee,Jae Ho Kim

Bioengineering & translational medicine 8:e10562 PubMed37693053

2023

Dual gene-activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin-1.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Weng,Min Yang,Wei Zhang,Ronghua Jin,Sizhan Xia,Manjia Zhang,Pan Wu,Xiaojie He,Chunmao Han,Xiong Zhao,Xingang Wang

International journal of nanomedicine 18:2821-2838 PubMed37273285

2023

Differences in the Cell Type-Specific Toxicity of Diamond Nanoparticles to Endothelial Cells Depending on the Exposure of the Cells to Nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Mateusz Wierzbicki,Katarzyna Zawadzka,Barbara Wójcik,Sławomir Jaworski,Barbara Strojny,Agnieszka Ostrowska,Artur Małolepszy,Marta Mazurkiewicz-Pawlicka,Ewa Sawosz

EMBO reports 23:e52977 PubMed35695065

2022

Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R.

Applications

Unspecified application

Species

Unspecified reactive species

Seung Hee Seo,Soo-Yeon Hwang,Seohui Hwang,Sunjung Han,Hyojin Park,Yun-Sil Lee,Seung Bae Rho,Youngjoo Kwon

Biomedicines 10: PubMed35203627

2022

Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mahendra Jadhao,Chun-Lin Chen,Wangta Liu,Dhanashri Deshmukh,Wei-Ting Liao,Jeff Yi-Fu Chen,Ritesh Urade,Eing-Mei Tsai,Sheng-Kai Hsu,Li-Fang Wang,Chien-Chih Chiu

International journal of oncology 60: PubMed35103286

2022

Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bayarbat Tsevegjav,Atsushi Takano,Ming Zhu,Yoshihiro Yoshitake,Masanori Shinohara,Yataro Daigo

APL bioengineering 5:026104 PubMed34027283

2021

Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Mathieu Danoy,Yannick Tauran,Stephane Poulain,Rachid Jellali,Johanna Bruce,Marjorie Leduc,Morgane Le Gall,Yuta Koui,Hiroshi Arakawa,Francoise Gilard,Bertrand Gakiere,Yukio Kato,Charles Plessy,Taketomo Kido,Atsushi Miyajima,Yasuyuki Sakai,Eric Leclerc

View all publications

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Human Angiogenesis Antibody Array - Membrane (43 Targets)

Multiplex Protein Detection - Human Angiogenesis Antibody Array - Membrane (43 Targets) (AB193655)

Key facts

Assay type

Reacts with

Target

Applications

Detection method

Assay Platform

Sample types

Reactivity data

Product details

What's included?

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Additional targets

Publications (15)

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