ab197445 can be used for quantitative measurement of 40 Human Growth Factors.
Images
Key facts
- Assay type
- Quantitative
- Reactive species
- Human
- Target
- BDNF
(See target data below) - Assay Platform
- Multiplex
Target data
Function
Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Neurotrophic factor BDNF precursor form. Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).
Additional Targets
AREG, NGF, FGF2, BMP4, Bone morphogenetic protein 5, BMP7, EGF, EGFR, PROK1, FGF4, FGF7, GDF15, GDNF, GH1, HBEGF, HGF, IGF1, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, INS, CSF1R, NGFR, NTF3, NTF4, TNFRSF11B, PDGFA, PGF, KITLG, KIT, Protransforming growth factor alpha, TGFB1, TGFB3, VEGFA, VEGFD, KDR, FLT4
Alternative names
Neurotrophic factor BDNF precursor form, proBDNF, Abrineurin, Brain-derived neurotrophic factor, BDNF
What's included?
Recommended products
ab197445 can be used for quantitative measurement of 40 Human Growth Factors.
Key facts
- Assay type
- Quantitative
- Reactive species
- Human
- Target
- BDNF
- Detection method
- Fluorescent
- Assay Platform
- Multiplex
- Sample types
- Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- -20°C
Notes
ab197445 can be used for quantitative measurement of 40 Human Growth Factors. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.
Targets names: AR, BDNF, bFGF, BMP-4, BMP-5, BMP-7, β-NGF, EGF, EGF R, EG-VEGF, FGF-4, FGF-7, GDF-15, GDNF, GH, HB-EGF, HGF, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-6, IGF-I, Insulin, MCSF R, NGF R, NT-3, NT-4, OPG, PDGF-AA, PIGF, SCF, SCF R, TGFα, TGFβ1, TGFβ3, VEGF, VEGF R2, VEGF R3, VEGF-D.
Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 µL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don’t have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. The standard is affinity purified. "
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3 product images
Multiplex Protein Detection - Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445)
Assay summary for Abcam Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445).
Multiplex Protein Detection - Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445)
Array map for Abcam Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445).
Multiplex Protein Detection - Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445)
Standard Curve obtained using Abcam Human Growth Factor Antibody Array (40 Targets) - Quantitative (ab197445).
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