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AB193662

Human RTK Phosphorylation Antibody Array -Membrane (71 Targets)

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(8 Publications)

ab193662 can be used for the simultaneous detection of 71 phosphorylated Human receptor tyrosine kinases (RTKs) in cell and tissue lysates.

View Alternative Names

HTK, MYK1, TYRO11, EPHB4, Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, EPH, EPHT, EPHT1, EPHA1, Ephrin type-A receptor 1, hEpha1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH, CD331, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, FGFR1, Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, N-sam, Proto-oncogene c-Fgr, bFGF-R-1, FLT-2, ERBB, ERBB1, HER1, EGFR, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, Tyrosine-protein kinase Lck, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK, LSK, LCK, C20orf148, SRMS, Tyrosine-protein kinase Srms, TRKB, NTRK2, BDNF/NT-3 growth factors receptor, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, Trk-B, Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, p59-Fyn, SLK, FYN, CD340, HER2, MLN19, NEU, NGL, ERBB2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, MLN 19, CD140b, PDGFR, PDGFR1, PDGFRB, Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1, ACVRLK1, ALK1, ACVRL1, Activin receptor type-1-like, Activin receptor-like kinase 1, Serine/threonine-protein kinase receptor R3, TGF-B superfamily receptor type I, ALK-1, SKR3, TSR-I, UFO, AXL, Tyrosine-protein kinase receptor UFO, AXL oncogene, Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK, Cytoplasmic tyrosine-protein kinase BMX, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase, NTK38, ETK, BMX, ABL, JTK7, ABL1, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK, ECK, EPHA2, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, ETK, ETK1, HEK, TYRO4, EPHA3, Ephrin type-A receptor 3, EPH-like kinase 4, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, EK4, hEK4, Human embryo kinase, Eph-like tyrosine kinase 1, HEK8, SEK, TYRO1, EPHA4, Ephrin type-A receptor 4, EPH-like kinase 8, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, EK8, hEK8, BSK, EHK1, HEK7, TYRO4, EPHA5, Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EPH-like kinase 7, EHK-1, EK7, hEK7, EHK2, HEK12, EPHA6, Ephrin type-A receptor 6, EPH homology kinase 2, EPH-like kinase 12, EHK-2, EK12, EHK3, HEK11, EPHA7, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11, EHK-3, EK11, hEK11, EEK, HEK3, KIAA1459, EPHA8, Ephrin type-A receptor 8, EPH- and ELK-related kinase, EPH-like kinase 3, Tyrosine-protein kinase receptor EEK, EK3, hEK3, ELK, EPHT2, HEK6, NET, EPHB1, Ephrin type-B receptor 1, EPH tyrosine kinase 2, EPH-like kinase 6, Neuronally-expressed EPH-related tyrosine kinase, Tyrosine-protein kinase receptor EPH-2, EK6, hEK6, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5, EPHB2, Ephrin type-B receptor 2, Developmentally-regulated Eph-related tyrosine kinase, ELK-related tyrosine kinase, EPH tyrosine kinase 3, EPH-like kinase 5, Renal carcinoma antigen NY-REN-47, Tyrosine-protein kinase TYRO5, Tyrosine-protein kinase receptor EPH-3, EK5, hEK5, ETK2, HEK2, TYRO6, EPHB3, Ephrin type-B receptor 3, EPH-like tyrosine kinase 2, Embryonic kinase 2, Tyrosine-protein kinase TYRO6, EPH-like kinase 2, EK2, hEK2, Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6, HER3, ERBB3, Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, FAK, FAK1, PTK2, Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FRNK, PPP1R71, TYK3, FER, Tyrosine-protein kinase Fer, Feline encephalitis virus-related kinase FER, Fujinami poultry sarcoma/Feline sarcoma-related protein Fer, Proto-oncogene c-Fer, Tyrosine kinase 3, p94-Fer, CD332, BEK, KGFR, KSAM, FGFR2, Fibroblast growth factor receptor 2, FGFR-2, K-sam, Keratinocyte growth factor receptor, SRC2, FGR, Tyrosine-protein kinase Fgr, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr, PTK5, RAK, FRK, Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck, HCK, CD221, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, IGF1R, CD220, Insulin receptor, IR, INSR, EMT, LYK, ITK, Tyrosine-protein kinase ITK/TSK, Interleukin-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk, IL-2-inducible T-cell kinase, Tyrosine-protein kinase JAK3, Janus kinase 3, Leukocyte janus kinase, JAK-3, L-JAK, JAK3, TYK1, LTK, Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, JTK8, LYN, Tyrosine-protein kinase Lyn, Lck/Yes-related novel protein tyrosine kinase, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, CTK, HYL, MATK, Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, CHK, CD115, FMS, CSF1R, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, Proto-oncogene c-Fms, CSF-1-R, CSF-1R, M-CSF-R, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor, MUSK, CD271, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor, FAK2, PYK2, RAFTK, PTK2B, Protein-tyrosine kinase 2-beta, Calcium-dependent tyrosine kinase, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, Focal adhesion kinase 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, CADTK, CAK-beta, CAKB, FADK 2, CDHF12, CDHR16, PTC, RET51, RET, Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, NTRKR1, ROR1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR2, ROR2, Tyrosine-protein kinase transmembrane receptor ROR2, JTK5A, RYK, Tyrosine-protein kinase RYK, CD117, SCFR, KIT, Mast/stem cell growth factor receptor Kit, Piebald trait protein, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PBT, Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK, PSCTK4, TEC, Tyrosine-protein kinase Tec, TIE, TIE1, Tyrosine-protein kinase receptor Tie-1, CD202b, TIE2, VMCM, VMCM1, TEK, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK, hTIE2, Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1, Non-receptor tyrosine-protein kinase TYK2, TYK2, CD309, FLK1, VEGFR2, KDR, Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, FLK-1, VEGFR3, FLT4, Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, FLT-4, CD140a, PDGFR2, RHEPDGFRA, PDGFRA, Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, PTK4, RLK, TXK, Tyrosine-protein kinase TXK, Protein-tyrosine kinase 4, Resting lymphocyte kinase, CD331, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, FGFR1, Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, N-sam, Proto-oncogene c-Fgr, bFGF-R-1, FLT-2

1 Images
Multiplex Protein Detection - Human RTK Phosphorylation Antibody Array -Membrane (71 Targets) (AB193662)
  • Multiplex Protein Detection

Unknown

Multiplex Protein Detection - Human RTK Phosphorylation Antibody Array -Membrane (71 Targets) (AB193662)

Typical images obtained with Abcam Human RTK Phosphorylation Antibody Array -Membrane (71 Targets) ab193662. These membranes were probed with conditioned media from two different cell lines. Membranes were exposed to film at room temperature for 1 minute.

Key facts

Reacts with

Human

Target

EPHB4

target

Applications

Multiplex Protein Detection

applications

Sample types

Tissue Lysate, Cell Lysate

Reactivity data

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Product details

ab193662 can be used for the simultaneous detection of 71 phosphorylated Human receptor tyrosine kinases (RTKs) in cell and tissue lysates.

Targets: ALB1, ACK1, ALK, Axl, Blk, BMX, Btk, Csk, Dtk, EGFR, EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4, EphB6, ErbB2, ErbB3, ErbB4, FAK, FER, FGFR1, FGFR2, FGFR2 (α isoform), Fgr, FRK, Fyn, Hck, HGFR, IGF-I R, Insulin R (CD220), Itk, JAK1, JAK2, JAK3, LCK, LTK, Lyn, MATK, M-CSFR, MUSK, NGFR (TNFRSF16), PDGFR-α, PDGFR-β, PYK2, RET, ROR1, ROR2, ROS, RYK, SCF R (CD117/c-kit), SRMS, SYK, Tec, Tie-1, Tie-2, TNK1, TRKB, TXK, Tyk2, TYRO10 (DDR2/TKT), VEGFR2, VEGFR3, ZAP70.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

What's included?

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C

Product protocols

Target data

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
See full target information EPHB4

Additional targets

ACVRL1,AXL,Tyrosine-protein kinase Blk,BMX,ABL1,Tyrosine-protein kinase CSK,EGFR,EPHA1,EPHA2,EPHA3,EPHA4,EPHA5,EPHA6,EPHA7,EPHA8,EPHB1,EPHB2,EPHB3,EPHB6,ERBB2,ERBB3,PTK2,FER,FGFR1,FGFR1,FGFR2,FGR,FRK,Tyrosine-protein kinase Fyn,HCK,IGF1R,INSR,ITK,JAK3,LCK,LTK,LYN phospho Y418,MATK,CSF1R,Muscle, skeletal receptor tyrosine-protein kinase,NGFR,PDGFRA phospho Y572 + Y574,PDGFRB,PTK2B,RET,ROR1,ROR2,RYK,KIT,SRMS,SYK,TEC,TIE1,TEK,TNK1,NTRK2,TXK,TYK2,KDR,FLT4

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Translational lung cancer research 11:543-559 PubMed35529797

2022

Picropodophyllin inhibits the growth of pemetrexed-resistant malignant pleural mesothelioma via microtubule inhibition and IGF-1R-, caspase-independent pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Sun,Ryosuke Tanino,Xuexia Tong,Eshat Fahmida Haque,Yoshihiro Amano,Takeshi Isobe,Yukari Tsubata

Cell death & disease 13:256 PubMed35319011

2022

MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanzhou Zhang,Shunshun Liang,Bowen Xiao,Jingying Hu,Yechun Pang,Yuling Liu,Juan Yang,Junpin Ao,Lin Wei,Xiaoying Luo

Cells 11: PubMed35011716

2022

Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Izabela N F Gomes,Renato J da Silva-Oliveira,Luciane Sussuchi da Silva,Olga Martinho,Adriane F Evangelista,André van Helvoort Lengert,Letícia Ferro Leal,Viviane Aline Oliveira Silva,Stéphanie Piancenti Dos Santos,Flávia Caroline Nascimento,André Lopes Carvalho,Rui Manuel Reis

Frontiers in cell and developmental biology 9:781172 PubMed34957110

2021

The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Charlie Colin-Pierre,Nicolas Berthélémy,Nicolas Belloy,Louis Danoux,Vincent Bardey,Romain Rivet,Solène Mine,Christine Jeanmaire,François-Xavier Maquart,Laurent Ramont,Stéphane Brézillon

Anticancer research 41:583-599 PubMed33517263

2021

Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade.

Applications

Unspecified application

Species

Unspecified reactive species

Rashidra R Walker,Karen M Gallegos,Melyssa R Bratton,Kitani P Lemieux,Kun Zhang,Guangdi Wang,A Michael Davidson,Syreeta L Tilghman

International journal of oncology 57:139-150 PubMed32319597

2020

Knockdown of GSG2 inhibits prostate cancer progression in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Yu,Yuanyuan Lin,Xinping Xu,Weipeng Liu,Dan Tang,Xiaochen Zhou,Gongxian Wang,Yi Zheng,An Xie

Respiratory research 20:270 PubMed31791326

2019

Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuexia Tong,Ryosuke Tanino,Rong Sun,Yukari Tsubata,Tamio Okimoto,Mayumi Takechi,Takeshi Isobe

Scientific reports 9:10394 PubMed31316108

2019

Knockout of glucosidase II beta subunit inhibits growth and metastatic potential of lung cancer cells by inhibiting receptor tyrosine kinase activities.

Applications

Unspecified application

Species

Unspecified reactive species

Worapong Khaodee,Suruk Udomsom,Phraepakaporn Kunnaja,Ratchada Cressey
View all publications
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