ab197461 can be used for quantitative measurement of 120 Mouse cytokines.
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed:8134392).
Mok, Csf2rb, Vegfd, Cxcl12, Met, Il21, Pro-epidermal growth factor, Tyro3, Slpi, Tnfrsf11b, Tnfrsf1b, Ccl3, Ccl1, Lgals1, Spp1, Ace, Il1rl1, Il10, Il15, Trem1, Sell, Hepatocyte growth factor, Cxcl16, Ccl9, Il17a, Lepr, Madcam1, Flt1, Il2ra, Tnf, Mme, Il2, Tnfrsf19, Dickkopf-related protein 1, Mmp9, Galectin-3, F11r, Igfbp6, Growth arrest-specific protein 6, Cd40, Tnfrsf13b, Tnfrsf18, Ccl12, Ccl2, Ctla4, Mfge8, Ccl17, Vegfd, Cxcl12, Met, Il21, Pro-epidermal growth factor, Tyro3, Slpi, Tnfrsf11b, Tnfrsf1b, Ccl3, Ccl1, Lgals1, Spp1, Ace, Il1rl1, Il10, Il15, Trem1, Sell, Hepatocyte growth factor, Cxcl16, Ccl9, Il17a, Lepr, Madcam1, Flt1, Il2ra, Tnf, Mme, Il2, Tnfrsf19, Dickkopf-related protein 1, Mmp9, Galectin-3, F11r, Igfbp6, Growth arrest-specific protein 6, Cd40, Tnfrsf13b, Tnfrsf18, Ccl12, Ccl2, Ctla4, Mfge8, Ccl17, Axl, Ccl11, Ccl19, Ccl20, Ccl22, Ccl24, Ccl5, Cd27, Cd40lg, CD70, Csf1, Csf3, Ctf1, Cx3cl1, Cxcl1, Cxcl11, Cxcl13, Cxcl2, Cxcl5, Cxcl9, Dcn, Eng, Faslg, Fcgr2, Fgf2, Flt3lg, Flt4, Gas1, Icam1, Ifng, Ifnl2, Igf1, Igfbp2, Igfbp3, Igfbp5, Il12a, Il12b, Il13, Il17f, IL1A_MOUSE, Il1b, Il1rn, Il20, Il23a, IL-25, Il3, Il4, Il5, Il6, Il7, Il9, Kitlg, Lep, Pf4, Prl, Ptx3, Retn, Sele, Selp, Spint1, Thpo, Tnfrsf1a, Tnfrsf8, Tnfrsf9, Tnfsf12, Tnfsf18, Tnfsf8, Tslp, Vcam1, Vegfa, Xcl1
Sdf1, Cxcl12, Stromal cell-derived factor 1, SDF-1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, Thymic lymphoma cell-stimulating factor, TPAR1, PBSF, TLSF
ab197461 can be used for quantitative measurement of 120 Mouse cytokines.
ab197461 can be used for quantitative measurement of 120 Mouse cytokines. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.
Targets names:
Array A: Axl, CD27L, CD30T, CD40, CXCL16, EGF, E selectin, Fractalkine, GITR, HGF, IGFBP-2, IGFBP-3, IGFBP-5, IGFBP-6, IGF-I, IL-12p70, IL-17E, IL-17F, IL-1ra, IL-2 Rα, IL-20, IL-23, IL-28, I-TAC, MDC, MIP-2, MIP-3α, OPN, OPG, Prolactin, Pro-MMP-9, P selectin, Resistin, SCF, SDF-1α, TPO, VCAM-1, VEGF, VEGF-D.
Array B: bFGF, BLC, CD30L, Eotaxin, Eotaxin-2, Fas L, GCSF, GM-CSF, ICAM-1, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12p40, IL-13, IL-15, IL-17, IL-21, KC, Leptin, LIX, MCP-1, MCP-5, M-CSF, MIG, MIP-1α, MIP-1γ, PF-4, RANTES, TARC, TCA-3, TNFα, TNFRI, TNFRII.
Array C: 4-1BB, ACE, ALK-1, CT-1, CD27, CD40L, CTLA-4, Decorin, Dkk-1, Dtk, Endoglin, Fcγ RIIB, Flt-3 L, Galectin-1, Galectin-3, Gas 1, Gas 6, GITR L, HAI-1, HGF R, IL-1 R4, IL-3 Rβ, IL-9, JAM-A, Leptin R, L Selectin, Lymphotactin, MadCAM-1, MFG-E8, MIP-3β, Neprilysin, Pentraxin 3, RAGE, TACI, TREM-1, TROY, TSLP, TWEAK R, VEGF R1, VEGF R3.
Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 μL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don't have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. The standard is affinity purified. "
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